Milk Thistle Herbal Extract for Hepatitis B, Dr.Abhay Kumar pati, USA

By: Best Nutrition Inc
 
 
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HAYWARD, Calif. - Dec. 18, 2016 - PRLog -- Silybum marianum  or milk thistle

Dr.Abhay Kumar Pati, CEO Best Nutrition Products Inc

Hayward, CA

Milk Thistle  has other common names include cardus marianus ,blessed milkthistle,Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle. This species is an annual or biennial plant of the Asteraceae family. Milk thistle gets its name from the milky white fluid that comes from the plant's leaves when they are crushed.

Background
Milk thistle is native to southern Europe, southern Russia, Asia Minor, and northern Africa. It also grows in North and South America and South Australia.

Silymarin is considered to be the main component of milk thistle seeds, but the terms "milk thistle" and "silymarin" often are used interchangeably.

Historically, people have used milk thistle for liver disorders, such as hepatitis and cirrhosis, and gallbladder problems.

Silymarin is the most commonly used herbal supplement in the United States for liver problems.

Plant Description
Milk thistles can grow to be 30 to 200 cm (12 to 79 in) tall, and have an overall conical shape. The approximate maximum base diameter is 160 cm (63 in). The stem is grooved and more or less cottony. The largest specimens have hollow stems.

The leaves are oblong to lanceolate. They are either lobate or pinnate, with spiny edges. They are hairless, shiny green, with milk-white veins.

The flower heads are 4 to 12 cm long and wide, of red-purple colour. They flower from June to August in the North or December to February in the Southern Hemisphere (summer through autumn).

The bracts (https://en.wikipedia.org/wiki/Bract) are hairless, with triangular, spine-edged appendages, tipped with a stout yellow spine.

The achenes (https://en.wikipedia.org/wiki/Achene) are black, with a simple long white pappus (https://en.wikipedia.org/wiki/Pappus_(flower_structure), surrounded by a yellow basal ring.

Chemistry
Traditional milk thistle extract is made from the seeds, which contain approximately 4–6% silymarin. The extract consists of about 65–80% silymarin (a flavonolignan complex) and 20–35% fatty acids, including linoleic acid. Silymarin is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin) and one flavonoid (taxifolin).Silibinin, a semipurified fraction of silymarin, is primarily a mixture of 2 diastereoisomers, silybin A and silybin B, in a roughly 1:1 ratio.

Quercetin and the dihydro varient known as Taxifolin.

Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3-sulphate of Kaempferol.

Apigenin (and 7-O-Glucoside, 4,7-Diglucoside, and 7-O-Glucuronide

Eriodyctiol, Chrysoeriol, and Naringin

5,7-Dihydroxychromone

Vitamin E at 0.038%

Sterols (cholesterol, campesterol, stigmasterol and sitosterol) at 0.63%

The leaves further contain: Luteolin and its 7-O-Glucoside,Triterpene acetate,Fumaric acid.

When processed into an ethanolic extract and sold as Milk Thistle Extract (most common supplemental form), the composition tends to be; 65-80% 'Silymarin' (concentrated from 1.5-3% of the plant)

20-35% Fatty acids (Linoleic acid 60%, Oleic acid 30%, and Palmitic acid 9%; roughly

The term 'Flavonolignans' is used to refer to seven compounds with the prefix of 'Sily-' or 'Isosily-'. These compounds are pictured below, with changes at the α/β carbons confering the other isomers (A and B in the case of Silybinin and Isosilibin, Silychristine in the case of Isosilichristine; Silydianin nor Taxifolin have known isomers in the Silymarin mixture).Milk Thistle as a herb contains a variety of compounds (if eating the thistle or buying Silybum Marianum seeds whole), but most studies use an ethanolic extract with a high Silymarin component; this Silymarin component is mostly just 7 flavonolignans that are seen as unique to Milk Thistle

What are the Benefits of Milk Thistle?
Over the past forty years, intensive chemical, pharmacological and clinical research has confirmed the mechanisms of action and therapeutic value of milk thistle in a wide range of human liver-related and non-liver-related conditions.

Liver related conditions indicating the use of milk thistle are varied:

Alcoholic cirrhosis

Chronic active hepatitis

Drug and alcohol induced liver damage

Acute viral hepatitis

Fatty liver, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH)
Fibrosis and Cirrhosis

Media Contact
Dr.Abhay Kumar Pati
dr.kumarpati@bestnutrition.com
15104779116
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Tags:Milk Thistle, Sylmarin, Nutrient
Industry:Biotech
Location:Hayward - California - United States
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