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Follow on Google News | Small and extremely resilient – the secrets of black fungiBy: Austrian Science Fund FWF They are true survival artists, not minding the cold any more than they do heat. Whether their environment offers little or plentiful oxygen, is wet, salty, dry or has contaminated soils – the black fungi keep their cool and feel at home in even the most inhospitable of living conditions. How do they do that? "To our great surprise, the fungi show almost no stress response at all. This means something in their structure makes them inherently resistant to stress", relates Katja Sterflinger. With the support of the Austrian Science Fund FWF, the microbiologist used a climate chamber to simulate different stress situations as the fungi encounter them in climatically extreme regions such as the Arctic or deserts. She first observed how the cells of the fungi, or, more precisely, its proteins, react to cold, heat, ozone or aridity. Unique "protein tool" Katja Sterflinger heads the "Extremophile Center" at the Vienna Institute of BioTechnology (VIBT), University of Natural Resources and Life Science. The climate chambers, built specifically for the Institute, and the use of cutting-edge sequencing technologies have made it possible for the first time to identify the proteins of black fungi. "This was very difficult, because they are not like or even comparable to anything else we have seen so far", notes Sterflinger. The researchers have now learned that the "microcolonial fungi", as the technical term goes, have a unique protein system that enables them to grow both at 0° C or at 45° C. The microbes even survived a simulated trip to Mars. All it takes them to achieve that is some minor molecular adjustment. "Depending on whether it is hot or cold, the fungi will change a little. But that is just fine-tuning" Understanding cellular processes In a next step, the team headed by Sterflinger matched the protein data yield with the transcriptome data, i.e. they analysed the sequence of cellular processes. The researchers discovered that the cellular secret seems to be less related to the proteins than to the non-coding RNA (ribonucleic acid). These molecules are active in the cell without being translated into proteins. While their biological functions had been largely undetermined until recently, it is now known that they have an important role in regulating a variety of cellular processes. After all, only two percent of the genetic material that is actively read is translated into proteins. The exceptional talent of "Exophiala dermatitidis" Among the hundreds of fungal strains the Viennese researchers have investigated to date, "Exophiala dermatitidi" Medical focus Instead, the experts from Vienna's University of Natural Resources and Life Science now focus on medical issues and have set out to investigate the molecules of the pathogenic "Exophiala dermatitidis" https://scilog.fwf.ac.at/ End
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