NEW ROCHELLE, N.Y. -
Nov. 9, 2016 -
PRLog -- A new study demonstrates that non-blood cell forming stem cells present in human bone marrow play an important role in maintaining the hematopoietic microenvironment, and these stromal cells appear to retain full self-renewal potential after primary and secondary transplantations, according to an article published in
Stem Cells and Development, a peer-reviewed journal from
Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com/)
. The article is available free on the
Stem Cells and Development (http://online.liebertpub.com/
doi/full/10.1089/
scd.2016.0169)
website.
In the article "Human Non-Hematopoietic CD271
pos/CD140a
low/neg Bone Marrow Stroma Cells Fulfill Stringent Stem Cell Criteria in Serial Transplantations (http://online.liebertpub.com/
doi/full/10.1089/
scd.2016.0169)
," the bone marrow stromal stem cells (BMSCs) were shown to have the signature characteristics of self-renewing stem cells capable of differentiating into many different types of skeletal cell lines. Coauthors
Roshanak Ghazanfari, Hongzhe Li, Dimitra Zacharaki, Hooi Ching Lim, and
Stefan Scheding, University of Lund and Skane University Hospital, Lund, Sweden, provided the first demonstration of the self-renewal and differential potential of human BMSCs in a serial transplantation experiment performed in mice.
"This elegant paper employs a unique profile and groundbreaking techniques to demonstrate that a subfraction of adult BMSCs fulfill stem cell criteria in serial transplantations,"
says Editor-in-Chief
Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
About the Journal
Stem Cells and Development (
http://www.liebertpub.com/scd) is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed on the
Stem Cells and Development (http://www.liebertpub.com/
scd) website.
About the Publisher
Mary Ann Liebert, Inc., publishers (
http://www.liebertpub.com/) is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including
Cellular Reprogramming, Tissue Engineering, and
Human Gene Therapy. Its biotechnology trade magazine, GEN (
Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the
Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com/)
website.