MAR - A Fluorescent Hypoxia-Detection Probe for Live Cell Imaging

The MAR Hypoxia Detection Probe is a novel fluorogenic reagent for hypoxia detection in living cells. It is non-fluorescent when living cells are in environments with normal oxygen concentrations, but becomes fluorescent when oxygen levels decline.
 
GÖTTINGEN, Germany - April 27, 2016 - PRLog -- Hypoxia - a pathological condition in which a region of the body is deprived of an adequate oxygen supply - is closely related to a wide area of diseases, including cancer and ischemia.

The MAR Hypoxia Detection Probe is a novel fluorogenic compound for hypoxia detection in living cells. It is non-fluorescent when living cells/tissues are in an environment with normal oxygen concentrations and becomes fluorescent when oxygen levels decline. This is due to the reduction of MAR under hypoxic conditions. MAR is able to work under a wide pH range and detects even mild hypoxia in which O2 concentration is around 5% in living cells.

These properties - together with the fact that MAR is cell-permeant - make it a highly useful tool for, e.g., cancer research. Hypoxic tumor cells are an attractive target for the discovery and development of novel cancer therapies - both because of the central role of tumor hypoxia in treatment resistance and cancer progression - and as hypoxia provides a basis for selective targeting and the sparing of normoxic cells elsewhere in the body.

Features

• Fluorogenic imaging probe for detection of hypoxia
• Gain of signal assays with the highest dynamic range for hypoxic conditions compared to normoxic environment
• Detects hypoxia in living cells by emitting fluorescence in low oxygen environments
• Brightly-green fluorescence upon reductive cleavage
• Excitation wavelength 498 nm / emission wavelength 520 nm
• Suitable for live cell imaging, flow cytometry, and tissue experiments
• As sensitive as pimonidazole
• Easy to use - just add to cell culture media and image
• Cell-permeant
• Unlike pimonidazole, MAR does not require immunostaining

Application

• Detecting hypoxic conditions in 2D and 3D cultures (spheroids), neurons …
• Detection of tumors in small animal model systems

MAR Hypoxia Detection Probe is manufactured by GORYO Chemical Inc., Japan, and sold in Germany by MoBiTec GmbH. For details on MAR please see:

http://www.mobitec.com/cms/products/bio/07_fluores_tec/hy...

About MoBiTec GmbH

MoBiTec GmbH
(Goettingen, Germany) is a privately held company (founded in 1987) that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.

In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.

http://www.mobitec.com

Contact
MoBiTec GmbH
Goettingen, Germany
***@mobitec.com
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Tags:Hypoxia, Cancer, Ischemia
Industry:Medical
Location:Göttingen - Lower Saxony - Germany
Subject:Products
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