Unique Cytochrome P450 Activity and Inhibitor Screening Assays from BioVision!

Isoform-specific, highly sensitive fluorescence-based assay kits for measuring activity of Cytochrome P450 (CYP) enzymes (3A4, 2D6, 2C19 etc.) or for screening ligands (substrates, inhibitors. modulators) that affect CYP function.
 
 
CYP3A4 press release
CYP3A4 press release
MILPITAS, Calif. - Sept. 8, 2015 - PRLog -- BioVision proudly announces the launch of a unique line of Cytochrome P450 (CYP) activity and ligand screening kits which use specific fluorescent substrates and validated inhibitors for each CYP isoform. The detection chemistry offers low signal-to-noise ratio for kinetic measurements like never before. These kits come with active human P450 enzymes coexpressed with NADPH reductase in one single membrane system (Check out our EZCyp™ Active Human Cytochrome P450 product line link below). This positive control allows data validation and inhibitor rank-ordering with absolute confidence.

Key Features:

o Easy-to-use, highly sensitive and quantitative
o High Throughput-compatible
o Coexpressed Active human P450-NADPH Reductase combo included
o Validated with pooled human liver microsomes and specific inhibitors

Applications:

o Rapid assessment of native/recombinant CYP activity in lysates or microsomal fractions prepared from tissues or cells.
o Screening of drugs and novel ligands for interaction with native/recombinant CYPs.
o Development of structure-activity relationship (SAR) models to predict CYP inhibition liability of novel compounds.
o Prediction of adverse drug-drug interaction potential and bioavailability for compounds metabolized by CYPs

BioVision's Drug Metabolism Assay kit portfolio:http://www.biovision.com/drug-metabolism-and-disposition-... and EZCyp™ Active Human Cytochrome P450 product line: http://www.biovision.com/search/results.html?keywords=EZC...

Contact
poulomi acharya
***@biovision.com
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Tags:Drug Metabolism, Cytochrome P450, Hepatic Metabolism
Industry:Biotech
Location:Milpitas - California - United States
Subject:Products
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Page Updated Last on: Sep 08, 2015
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