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Follow on Google News | Digital Course: Dealing With The Blood-Brain BarrierPart of the Cambridge Healthtech Institute Digital Course Library
Dealing With The Blood-Brain Barrier Digital Course is available in Digital Download, Single Copy and a Site License. This course includes 4 presentations and has over 175 slides. Agenda at a Glance: · The physiological basis for the “barrier” nature of the BBB · Experimental approaches (in vitro/in vivo) that are available for screening for brain penetration · Medicinal chemistry perspective on in vitro/in silico approaches for optimizing CNS penetration · Multi-parameter optimization (MPO) for CNS penetration · In vivo examples where all these concepts are applied together, e.g., consideration of free fractions in various compartments in relation to in vitro pharmacology values · Projecting human receptor occupancies considering species differences in affinity, free fraction · Exposure targeting for biomarker studies Presentation Speakers Include: · Douglas Spracklin, Ph.D., Director, Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc. · Christopher L. Shaffer, Ph.D., Associate Research Fellow, Pharmacokinetics, Dynamics & Metabolism, Pfizer, Inc. · Travis T. Wager, Ph.D., Associate Research Fellow, Neuroscience Discovery Medicinal Chemistry, Pfizer, Inc. For more information on this course, visit: http://www.worldpharmacongress.com/ About Cambridge Healthtech Institute (http://www.healthtech.com) Cambridge Healthtech Institute (CHI), founded in 1992, is the industry leader in providing superior-quality scientific information to eminent researchers and business experts from top pharmaceutical, biotech, and academic organizations. Delivering an assortment of resources such as events, reports, publications and eNewsletters, CHI's portfolio of products include Cambridge Healthtech Institute Conferences, Barnett Educational Services, Insight Pharma Reports, Cambridge Marketing Consultants, Cambridge Meeting Planners, Knowledge Foundation and Cambridge Healthtech Media Group, which includes Bio-IT World, Clinical Informatics News, and Diagnostics World News. End
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