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NAMSR News: Biodegradable thin film could deliver steady drug dose in body for a year
Instead of ingesting pain medication which may come with side effects.A new method based on nanotechnology will be able to deliver drug incrementally in the part of the body that needs it, for up to a year.
Normally, for long-term drug release, you would need to insert a reservoir or device for holding the drug back, and this is usually something non-degradable, that has to be retrieved when the dose is exhausted.
But the team thinks with their technique, which uses biodegradable film, you could implant it and it would release the drug for about a year, and you would not have to go in and retrieve it - it would simply biodegrade.
In their paper, the developers describe how the duration of controlled-release is significantly longer with their refined technique than that achieved by most commercially available biodegradable products.
To get the technique right, the team had to tackle a difficult problem in localized drug delivery: how to ensure that the process through which the drug is released occurs at the right pace.
They had to come up with a mechanism that limits the rate of hydrolysis - the process where water in the body breaks down the bonds that hold the drug in place and releases it into the target tissue.
Too much hydrolysis would release too much drug too quickly. The mechanism needs to allow the drug to be released in steady increments.
The solution they developed uses a "layer-by-layer"
In their paper, they describe how they tested the idea using diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) that is often prescribed for osteoarthritis and other pain or inflammatory conditions.
They bound the NSAID to thin layers of poly-L-glutamic acid, which comprises an amino acid that is absorbed in the body, and two other organic compounds.
In lab tests, the developers found the diclofenac was steadily released over 14 months, "far exceeding the duration noted in most previous reports, especially those from biodegradable matrices," they note.
To evaluate the effectiveness of the method in preserving drug potency, the developers tested how well the diclofenac released from the thin film blocked the activity of an enzyme that is key to inflammation - cyclooxygenase of COX.
They note that the diclofenac remained active after release, producing "substantial COX inhibition at a similar level" to pills. This showed the method of attaching and releasing the drug had not damaged it.
CANDIDATES WHO WANT TO BREAK INTO MEDICAL SALES:
RMSR® Medical Sales Certification offered by the National Association of Medical Sales Representatives is designed for entry level medical device sales reps. The course covers a wide array of topics pertaining to industry knowledge that candidates need to acquire before applying to medical sales positions.
The course and training helps to develop the industry skills, maximizing the candidates’ potential and goals, as well as making them feel valued and stimulated in their role when communicating with members of the medical community. By an applicant acquiring medical sales training and a RMSR Certification, it puts him/her in a position of strength and qualifies them for medical sales jobs. Medical knowledge is key in this industry and when communicating with doctors, surgeons, and nurses etc.
It is extremely important for representatives to use key terminology pertaining to the medical product he/she will be promoting. The only way to succeed in this industry is to garner actual sales. Doctors and Surgeons will not acknowledge a Sales Rep who is not proficient in essential medical terminology, knowledgeable of medical devices/equipment and the anatomy. For those lacking a solid sales background the RMSR course covers knowledge of medical selling techniques and regulation such as Effective Territory Management, Effective Networking, Medical Sales Ethical & Regulatory Guidelines and more.
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