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How to choose a Novel Oral Anticoagulant (NOAC) for stroke prevention in atrial fibrillation
Efficacy and safety of edoxaban in comparison with dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: An indirect comparison analysis
Previously, the only available oral anticoagulants were vitamin-K antagonists. Today, with the availability of four NOACs (dabigatran, rivaroxaban, apixaban and – most recently – edoxaban) clinicians have a choice and can match the drug to the patient, and vice versa. Moreover, individual preferences of the patient may be incorporated into the final decision about any future treatment.
Following the recent publication of the ENGAGE-AF trial with the Factor Xa inhibitor, edoxaban - biostatistician Flemming Skjøth, MSc, PhD, Aalborg University Hospital, Thrombosis Center, Aalborg, Denmark, and his team performed the first indirect comparison of safety and efficacy of edoxaban against the other NOACs, i.e. dabigatran, rivaroxaban and apixaban.
This recent analysis, published in the May 2014 issue of "Thrombosis and Haemostasis"
Efficacy of low-dose edoxaban was either similar or less effective than its competitors. When safety endpoints were compared, low-dose edoxaban emerged as the best, with the least bleeding The differences among the drugs also suggested that patient-related factors such as expected compliance, individual focus on efficacy and side-effects as well as renal function, shall be taken into account when selecting a drug.
By providing the current analysis, the authors have presented for the first time, comparisons of efficacy and safety of edoxaban with other NOACs. Still, the authors emphasized that their findings, similarly to previous indirect comparisons of NOACs, are not based on direct head-to-head comparisons (which remain the gold standaed), a reminder that the data should thus be considered with some caveats.
Skjøth F, Larsen TB, Hvilsted LR, et al. Efficacy and safety of edoxaban in comparison with dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: