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Follow on Google News | HemogloBind™ Cited In Research On Hemolytic Anemia In Mature ErythrocytesBy: Biotech Support Group Hikosaka, Keisuke, et al. "Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes (http://www.jbc.org/ Authors Hikosaka et al describe research on nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3) from red blood cells and its regulation of nicotinamide adenine dinucleotide. Detection of hemolytic anemia and splenomegaly in addition to reduced adenosine triphosphate (ATP) levels was noted in cells not containing Nmnat3. Glycolysis progression was stalled at the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) step as a deficiency of Nmnat3 led to lack of co-enzyme NAD. LC-MS/MS metabolomics and stable isotope tracer analysis revealed the impact of reduced NAD quantity in RBCs on glycolysis and pentose phosphate pathway. For selective extraction of hemoglobin from erythrocytes, the article states “Each sample was normalized by hemoglobin concentration at 20 µg/µl, and then hemoglobin was depleted using HemogloBind (http://www.biotechsupportgroup.com/ “We continue to find new uses of HemogloBind (http://www.biotechsupportgroup.com/ About Biotech Support Group LLC Biotech Support Group LLC is a leading developer of consumable proteomic, metabolomic and genomic sample preparation and enrichment products. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin depletion, Cleanascite™ Contact: Matthew Kuruc Biotech Support Group LLC 1 Deer Park Drive, Suite M Monmouth Junction NJ 08852 732-274-2866 Worldwide 800-935-0628 North America sales@biotechsupportgroup.com http://www.biotechsupportgroup.com End
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