First Program Announcement DSO National Labs Singapore Presenting Towards PCR-Free, Visual DNA Dete

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Point Of Care
Public Health


Boston - Massachusetts - US


BOSTON - Jan. 23, 2014 - PRLog --

BIODETECTION TECHNOLOGIES 2014 - the 22nd conference in our Detection Technologies conference series - is an internationally recognized meeting for experts in detection & identification of biological threats and point-of-care analytical methods. This conference will review feedback from the end-users on biodefense and biomedical technologies and explore the cutting-edge in R&D and commercialization efforts in the field, including:

•    Rapid biosensing, biodetection and analysis
•    Simultaneous detection of multiple threats and pathogens
•    Discovery and analysis of biosignatures for the detection of host response
•    Point-of-care/clinical applications for pathogen/virus/threat detection and identification
•    Point-of-care assays for resource limited, lab and clinical settings; mobile labs
•    Advances in microarray and sequencing technologies
•    Field-deployable devices: portability/compatibility/reliability/scalability
•    Non-PCR vs. PCR based detection techniques
•    Issues of sensitivity/testing/evaluation/validation
•    Animal and plant pathogens
•    Bioelectronics
•    DNA chips, nucleic acid sensors and aptasensors
•    Enzyme-based biosensors
•    Immunosensors
•    Lab-on-a-chip
•    Microfluidics and immobilisation technology
•    Natural & synthetic receptors (including MIPs)
•    Organism- and whole cell-based biosensors
•    Proteomics, single-cell analysis and cancer-cell detection

•    Signal transduction technology (including magneto, piezo, optical and direct electrochemical techniques)


Towards PCR-Free, Visual DNA Detection

Mahesh Uttamchandani, PhD, Assistant Professor, DSO National Laboratories, National University of Singapore, Singapore

We describe novel methods to detect DNA sequence specifically through color change reactions. To transduce molecular recognition events into visual readouts, we have engineered assays which have exploited split DNAzymes and gold nanoparticles. The G-quadruplex DNAzymes were successfully applied to the detection of Salmonella and Mycobacterium DNA, as well as in genotyping a single base difference from within human genomic DNA samples. This was the first time the approach was demonstrated starting from live genomic DNA samples. An integrated workflow was capable of detecting DNA samples through a color change within just 5-15 min (3). The gold nanoparticle method offered much greater sensitivity, enabling the detection of as little as 608 000 copies of the Salmonella genome, by eye, without the need for PCR amplification. These methods thus enable direct on-site visual detection, by bringing sophisticated DNA analysis capabilities to the point of care setting, without the need for cumbersome equipment or a power source.


Conductive DNA Real-Time Simultaneous Detection of Multiple Targets
Fred Albert, PhD, President, Bridger Technologies, Inc.

iTIRF – Cell Phone Based Biosensor for Molecular Diagnostics
Alexander N. Asanov, PhD, President and CSO, TIRF Labs, Inc

The Photonic Nose: A Versatile and Simple Sensing Tool
Leonardo Bonifacio, PhD, Research Scientist, Opalux Inc., Canada

A Fully Autonomous Biodetection System for Environmental Surveillance
Mark Burton, Northrop Grumman Corporation

Bioaerosol Standoff Detection Using Lidar Technology Allowing Cloud Mapping and Spectrometric LIF Classification
Sylvie Buteau, PhD, Scientist, Defence Research and Development Canada, Canada

Direct Multiplexed Virus Detection
John H. Connor, PhD, Professor, Dept of Microbiology, Boston University School of Medicine

SoundStream – A Microfluidic-Based Assay Platform for Rapid Portable Diagnostics
Arlene Doria, PhD, CEO, DEFINEQA Inc.

Enabling Point of Care Test Development for the STD Market
Joany Jackman, PhD, Investigator, Center for Point of Care Tests for STD, Johns Hopkins University School of Medicine

Host-response based biodetection by immunosignatures
Stephen Albert Johnston, PhD, Co-Director, Center for Innovations in Medicine, Professor, School of Life Sciences, Biodesign Institute, Arizona State University

Tool Box of Engineered Microfluidic Components Shortens Development Time and Reduce Risk
Leanna Levine, PhD, CEO, Aline, Inc.

Magneto-Hydrodynamic Focusing for Point of Care Applications
Christian Reis, Group Lead - Biotechnology Processes, Fraunhofer IPA, Germany

Application of a Recombinant Topoisomerase for the Specific Enrichment of Prokaryotic DNA
Natalia Sandetskaya, PhD, Fraunhofer Institute for Cell Therapy and Immunology IZI, Germany

Treatment Guiding Detection of Burkholderia
R. Paul Schaudies, PhD, CEO, GenArraytion, Inc.

A Novel Thermostable Viral DNA Polymerase Facilitates Point of Care Molecular Detection of DNA and RNA Targets
Hemanth Shenoi, PhD, Lucigen Corp

Automatic Online Real-Time Detection of Microcystin-LR Based on Optical Biosensing System
Han-Chang SHI, PhD, Professor, School of Environment, Tsinghua University, PR China

New MEMS-based Micro-Coriolis Density Measurement Technology
Mike Touzin, Endress+Hauser Flowtec, Switzerland

Mid-Infrared QC Lasers for Molecular Recognition
Mariano Troccoli, PhD, Director of Product Development, AdTech Optics, Inc.

Towards PCR-Free, Visual DNA Detection
Mahesh Uttamchandani, PhD, Assistant Professor, DSO National Laboratories, National University of Singapore, Singapore

Genomic-Based Approach for Tracking Pathogens
Willy Valdivia-Granda, PhD, CEO, Orion Integrated Biosciences Inc.

Microcantilever Enabled Biodetection
Rick Venedam, PhD, Senior Scientist, National Security Technologies, LLC

Point of Care Diagnostic Analysis of Samples in Complex Backgrounds
Brad Wright, PhD, Vice President, Bridger Technologies, Inc


Craig Wohlers
Knowledge Foundation
2193 Commonwealth Avenue, Box 398
Boston, MA  02135
Phone: (617) 232 7400 ext 205
Fax: (617) 232 9171

Craig Wohlers
617 232 7400
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Tags:Biodefense, Point Of Care, Public Health
Industry:Biotech, Defense
Location:Boston - Massachusetts - United States
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