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Novel Cardiac Gene Therapy Might Be Launched Soon to Reverse Heart Failure
American researchers have successfully developed a new type of treatment
By: Creative Biomart
Now the study has entered into end stage and is expected to soon be able to enter into clinical trials.
One of the study founders said that SUMO-1 gene therapy can effectively reduce heart enlargement and significantly improve cardiac function to maintain vital signs.
Heart failure is still a major factor for elder hospitalization. In the United States each year nearly 30 million people died because of the disease.
Heart failure is a variety of syndrome that is caused by cardiac structural or functional disorders-based ventricular filling and (or) impaired ejection ability.
About Gene SUMO1
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Source: Creative Biomart (http://www.creativebiomart.net/