NEW ROCHELLE, N.Y.
- Sept. 17, 2013
-- Contact: Vicki Cohn, Mary Ann Liebert, Inc, (914) 740-2100, ext. 2156, email@example.com
OptSwap Optimizes Microbial Strain Design for Production-Scale Bioprocessing
New Rochelle, NY—Using a new in silico method called OptSwap scientists can predict how to engineer microorganisms to increase the yield of high-value biobased chemicals produced by industrial-scale cell factories. This example of how advanced computational tools are being applied to genome-scale metabolic modeling in microbes illustrates the important contributions from the field of Systems Biology, as highlighted in a special research section in Industrial Biotechnology
, a peer-reviewed journal from Mary Ann Liebert Inc., publishers
. The articles are available on the Industrial Biotechnology
The article "Optimizing Cofactor Specificity of Oxidoreductase Enzymes for the Generation of Microbial Production Strains—OptSwap,"
) by Zachary King
and Adam Feist
, University of California, San Diego and Technical University of Denmark, Lyngby, describes the development of OptSwap. The authors identified microbial strain designs with significant advantages for the production of L-alanine, succinate, acetate, and D-lactate under the modeled conditions.
"The OptSwap method of King and Feist provides a great example of how systems approaches can enable more effective design and simulation of microbial strains,” says Guest Editor Nathan D. Price, PhD
, Associate Director, Institute of Systems Biology (Seattle, WA) and a member of the Industrial Biotechnology
IN DEPTH special section on Systems Biology includes review articles by Kieran Smallbone
(University of Manchester, UK) and Pedro Mendes
(Virginia Tech, Blacksburg): "Large-Scale Metabolic Models: From Reconstruction to Differential Equations" (http://online.liebertpub.com/doi/full/10.1089/ind.2013.0003
); Jacob Koskimaki, Anna Blazier, Andres Clarens,
and Jason Papin
(University of Virginia, Charlottesville):
"Computational Models of Algae Metabolism for Industrial Applications"
ind.2013.0012); Scott Harrison
and Markus Herrgård
(Technical University of Denmark, Hørsholm): "The Uses and Future Prospects of Metabolomics and Targeted Metabolite Profiling in Cell Factory Development"
and Manual Alberto Garcia-Albornoz
and Jens Nielsen
(Chalmers University of Technology, Göteborg, Sweden): "Application of Genome-Scale Metabolic Models in Metabolic Engineering."
Research articles by Hnin Aung, Susan Henry,
and Larry Walker
(Cornell University, Ithaca, NY): "Revising the Representation of Fatty Acid, Glycerolipid, and Glycerophospholipid Metabolism in the Consensus Model of Yeast Metabolism,"
and by Patrick Hyland
and Radhakrishnan Mahadevan
(University of Toronto, Canada) and Serene Lock-Sow Mun
(Universiti Teknologi Petronas, Tronoh Malaysia): "Prediction of Weak Acid Toxicity in Saccharomyces cerevisiae
Using Genome-Scale Metabolic Models" (http://online.liebertpub.com/
round out the special section.About the JournalIndustrial Biotechnology
ind), led by Co-Editors-in-
Chief Larry Walker, PhD,
Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY, and Glenn Nedwin, PhD, MoT
, CEO and President, Caisson Biotech, LLC, Davis, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture)
, in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends. Industrial Biotechnology
offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.About the Publisher
Mary Ann Liebert Inc., publishers
is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including Environmental Engineering Science
and Sustainability: The Journal of Record
. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News
(GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert Inc., publishers