NEW ROCHELLE, N.Y. -
Sept. 17, 2013 -
PRLog -- Contact: Vicki Cohn, Mary Ann Liebert, Inc, (914) 740-2100, ext. 2156, vcohn@liebertpub.com
OptSwap Optimizes Microbial Strain Design for Production-Scale Bioprocessing
New Rochelle, NY—Using a new in silico method called OptSwap scientists can predict how to engineer microorganisms to increase the yield of high-value biobased chemicals produced by industrial-scale cell factories. This example of how advanced computational tools are being applied to genome-scale metabolic modeling in microbes illustrates the important contributions from the field of Systems Biology, as highlighted in a special research section in
Industrial Biotechnology, a peer-reviewed journal from
Mary Ann Liebert Inc., publishers (http://www.liebertpub.com)
. The articles are available on the
Industrial Biotechnology website (http://www.liebertpub.com/
ind).
The article "Optimizing Cofactor Specificity of Oxidoreductase Enzymes for the Generation of Microbial Production Strains—OptSwap,"
(
http://online.liebertpub.com/doi/full/10.1089/ind.2013.0005) by
Zachary King and
Adam Feist, University of California, San Diego and Technical University of Denmark, Lyngby, describes the development of OptSwap. The authors identified microbial strain designs with significant advantages for the production of L-alanine, succinate, acetate, and D-lactate under the modeled conditions.
"The OptSwap method of King and Feist provides a great example of how systems approaches can enable more effective design and simulation of microbial strains,” says Guest Editor
Nathan D. Price, PhD, Associate Director, Institute of Systems Biology (Seattle, WA) and a member of the
Industrial Biotechnology Editorial Board.
The
IB IN DEPTH special section on Systems Biology includes review articles by
Kieran Smallbone (University of Manchester, UK) and
Pedro Mendes (Virginia Tech, Blacksburg): "Large-Scale Metabolic Models: From Reconstruction to Differential Equations" (
http://online.liebertpub.com/doi/full/10.1089/ind.2013.0003);
Jacob Koskimaki, Anna Blazier, Andres Clarens, and
Jason Papin (University of Virginia, Charlottesville):
"Computational Models of Algae Metabolism for Industrial Applications"
(
http://online.liebertpub.com/doi/full/10.1089/ind.2013.0012);
Scott Harrison and
Markus Herrgård (Technical University of Denmark, Hørsholm): "The Uses and Future Prospects of Metabolomics and Targeted Metabolite Profiling in Cell Factory Development"
(http://online.liebertpub.com/
doi/full/10.1089/
ind.2013.0008);
and
Manual Alberto Garcia-Albornoz and
Jens Nielsen (Chalmers University of Technology, Göteborg, Sweden): "Application of Genome-Scale Metabolic Models in Metabolic Engineering."
(http://online.liebertpub.com/
doi/full/10.1089/
ind.2013.0011)
Research articles by
Hnin Aung, Susan Henry, and
Larry Walker (Cornell University, Ithaca, NY): "Revising the Representation of Fatty Acid, Glycerolipid, and Glycerophospholipid Metabolism in the Consensus Model of Yeast Metabolism,"
(http://online.liebertpub.com/
doi/full/10.1089/
ind.2013.0013);
and by
Patrick Hyland and
Radhakrishnan Mahadevan (University of Toronto, Canada) and
Serene Lock-Sow Mun (Universiti Teknologi Petronas, Tronoh Malaysia): "Prediction of Weak Acid Toxicity in
Saccharomyces cerevisiae Using Genome-Scale Metabolic Models" (http://online.liebertpub.com/
doi/full/10.1089/
ind.2013.0004)
round out the special section.
About the JournalIndustrial Biotechnology (http://www.liebertpub.com/
ind), led by Co-Editors-in-
Chief
Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY, and
Glenn Nedwin, PhD, MoT, CEO and President, Caisson Biotech, LLC, Davis, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture)
, in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends.
Industrial Biotechnology offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.
About the Publisher
Mary Ann Liebert Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including
Environmental Engineering Science and
Sustainability: The Journal of Record. Its biotechnology trade magazine,
Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the
Mary Ann Liebert Inc., publishers website (http://www.liebertpub.com)
.