Chemical Computing Group's Dinner Course: A Uniform Framework for Computer-Aided Biologics Design

NEEDHAM, Mass. - March 22, 2013 - PRLog -- Chemical Computing Group will host a dinner short course in Boston, MA, on June 19, 2013, from 6:00-8:00 pm, on the conclusion of day one of CHI/Bio-IT World’s 13th annual Structure-Based Drug Design (SBDD) conference taking place at the Revere Hotel in Boston, MA.

Protein engineering plays a pivotal role in modulating the function, activity and physical properties of biologics. Representative strategies employed in protein engineering include rationale protein design and directed evolution. In general, disparate work has been done in applying computer-aided biologics design (CABD) to protein engineering for the development of novel biological therapeutics. Here, we describe a unified framework of in silico protein engineering tools and investigate its applicability to the modulation of protein properties such as affinity and stability. The course will cover current in silico technologies used in protein engineering and biologics design. More specifically, applications for visualizing, and analyzing mutations will be described. Tools for calculating surface properties such as electrostatic hot-spots or patches, as well as physicochemical properties will be presented. A number of case studies will be used to describe how residue scanning technology can be used to address challenges in species cross-reactivity, stability, and aggregation.

The course will be led by Chris Williams, Ph.D., Principal Scientist, Chemical Computing Group.  Chemical Computing Group endorsed its support as a corporate sponsor at CHI’s SBDD conference scheduled for June 19-21, 2013.

For more information or to register for the course and/or the Structure-Based Drug Design conference, visit http://www.healthtech.com/sbd.

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Contact:
James Prudhomme
Cambridge Healthtech Institute
781-972-5400
jprudhomme@healthtech.com