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Follow on Google News | Cerilliant Introduces 13C-Labeled Internal Standards for Thyroid Hormone Testing by LC-MS/MSCerilliant introduces Certified Spiking Solutions® for use in preparation of calibrators and controls of T4-13C6, T3-13C6, and reverse T3-13C6 for monitoring free and total thyroid hormone levels in serum or plasma by LC-MS/MS.
Disorders of thyroid metabolism affect millions of patients worldwide. Clinical diagnosis and treatment requires testing and monitoring of patient thyroid hormone levels. Currently most thyroid hormone assays are by radioimmunoassay (RIA) which has limited shelf life and lack specificity.1 In recent years there has been significant push to develop LC-MS/MS methods for quantitation of thyroid hormones with the potential for higher accuracy, better specificity, and the ability to quantitate the different thyroid hormones separately. The choice of internal standard in these LC-MS/MS methods is critical for accurate quantitation of analytes, especially those at low concentrations or where matrix effects are an important consideration such as in thyroid analysis. “Using 13C-labeled internal standards for thyroid analysis can eliminate potential issues such as isotopic exchange and minimize separation of later-eluting analytes from a higher substituted deuterium-labeled internal standard.” comments Josh Cooper, PhD and Cerilliant analytical scientist specializing in LC-MS/MS analysis. Cerilliant offers a wide selection of Certified Spiking Solutions® for use in clinical or diagnostic testing, endocrinology, toxicology, and therapeutic drug monitoring including Snap-N-Spike® About Cerilliant Cerilliant Corporation, located in Round Rock, Texas, is a global leader in providing certified reference standards for critical applications. The company has been providing certified reference materials for over 30 years. Cerilliant offers more than 3,000 catalog products and a full range of custom products and services that address the stringent and complex requirements of the pharmaceutical, clinical diagnostic, clinical/forensic toxicology, natural products, and environmental industries. Cerilliant sustains a modern, robust quality system which incorporates cGMP, GLP, and ISO requirements. We are accredited to ISO Guide 34 and ISO/IEC 17025 and certified to ISO 13485 and ISO 9001:2008. Cerilliant Corporation is a subsidiary of Sigma-Aldrich® References 1Wang, Dongli and Stapleton, Heather M., Analysis of Thyroid Hormones In Serum by Liquid Chromatography- End
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