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Advancements in technologies have enabled Bio-Synthesis to expand and include Long Oligos
Bio-Synthesis is able to synthesize ultra long oligonucleotides (RNA and DNA).
Longer constructs that required more choices like palindromes for restriction enzymes give researchers more flexibility. DNA UbermersTM are also used as an internal control template with or without certain SNP's and have been use in amplification reactions like Real-Time PCR and qPCR. All Oligo UbermersTM are delivered deprotected, desalted to remove small molecular impurities, and PAGE purified for extremely high purity needs. For even greater convenience, all Oligo UbermersTM are delivered lyophilized.
While there has been significant demand for long oligos, the yields in conventional DNA synthesis and the associated side reactions have been previously limited due to the length. Bio-Synthesis's expertise in artificial gene synthesis and microarray development provides the ability to synthesize thousands of single strand synthetic long DNA oligos using the best DNA synthesis reagents available. Optimized long oligo synthesis protocols permit high quality DNA oligomer with superior coupling efficiency through an entire DNA synthesis reaction. Each long custom DNA oligo is meticulously monitored during synthesis and controlled according to Bio-Synthesis’
As the capabilities of RNA analysis expand, the need to obtain a standardized RNA fragment has become increasingly important in the development of molecular diagnostic techniques. RNA oligos can be added and quantified at will, making them very important as reliable controls for each step of the RT-PCR protocol to ensure the accuracies of diagnostic test results. Many RNA based applications not only uses short RNA but very long RNA sequences. The typical RNA control fragment for RT-PCR, Spike-in control or transcript/mRNA for protein synthesis, require RNA fragments between 200 bases and a few thousand bases. Bio-Synthesis is uniquely positioned and capable to synthesizing long RNA fragment with greater length, quality and fast turnaround time.
Bio-Synthesis is a manufacturer of custom peptide synthesis, antibodies, bioconjugates, DNA, RNA, PNA, organic synthesis, microarrays, gene synthesis, cloning, detection kits, cell line authentication, and a diverse number of bimolecular products for the biomedical/life science community worldwide.
With over 27 years of experience producing custom products for both research and pharmaceutical use, BSI has developed a reputation for both small and large scale synthesis using optimal processes that meet your specifications. BSI is a U.S. based company, therefore all products are exclusively manufactured at the state-of-the-