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Inadequate Supply of Protein Building Blocks May Explain Pregnancy Failures in Cloning Experiments
An insufficient supply of amino acids in the mother’s uterus caused by abnormal maternal-embryo interactions may explain the developmental abnormalities and complications of pregnancy that result in the death of cloned bovine embryos.
Anna Groebner, Technische Universitaet Muenchen (Freising, Germany), and colleagues from Ludwig-Maximilians-
The authors show that the concentrations of several amino acids were reduced in samples from SCNT pregnancies compared to IVF pregnancies during the period preceding implantation of the embryos in the uterine lining. They report these findings and comment on their implications in the article entitled “Reduced Amino Acids in the Bovine Uterine Lumen of Cloned versus In Vitro Fertilized Pregnancies Prior to Implantation.”
“These results reveal that cloned embryos are sometimes unable to establish a normal relationship with the maternal environment. This important new insight highlights the importance and potential benefit of research to understand the mechanisms that are involved,” says Professor Sir Ian Wilmut, OBE, FRS, FRSE, Editor-in-Chief of Cellular Reprogramming and director of the MRC Centre for Regenerative Medicine in Edinburgh.
Cellular Reprogramming, published bimonthly in print and online, reflects the new focus in this evolving field. Advances in reprogramming cellular mechanisms are transforming biomedical research and offer new insights on the etiology, development, and potential treatment of various diseases. The Journal emphasizes novel approaches for understanding the cellular and molecular mechanisms that underlie the phenomenon of reprogramming. Coverage includes somatic cell nuclear transfer and reprogramming in early embryos; embryonic stem cells; nuclear transfer stem cells; generation of induced pluripotent stem (iPS) cells; epigenetics;
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