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Follow on Google News | Recent Study: R&D Trends: Rheumatoid Arthritis - Approaching an era of novel kinase inhibitorsFast Market Research recommends "R&D Trends: Rheumatoid Arthritis - Approaching an era of novel kinase inhibitors" from Datamonitor, now available
Datamonitor has identified a total of 153 products in development for rheumatoid arthritis. There is considerable interest in kinase inhibitors in the rheumatology field and they remain prominent across the pipeline in 2011. Notably, opinion leaders remain hopeful about Pfizer's tofacitinib (formerly tasocitinib) Features and benefits * Support R&D decision making by evaluating the competitive dynamics of the pipeline. * Analyze the various rheumatoid arthritis clinical trial designs, with a focus on trial duration, endpoints, and potential future changes. * Benchmark novel and existing therapies using the ideal target product profile identified by Datamonitor and access leading rheumatologist opinion. Highlights Early-stage (preclinical to Phase I) candidates account for 68% of the pipeline. Akin to late-stage projects, kinase and interleukin (IL) inhibitors are prominent. Opinion leaders are keen on IL-6 and -17, JAK and spleen tyrosine kinase inhibitors. Still, it remains to be seen where these early therapies could fit into an already crowded RA market. Late-stage trials in RA can have numerous designs. However, the design implemented and data collated are important because these directly impact labelling during drug approval. For example, studies over 3- to 6-months support an 'improvement in signs and symptoms' label, while 6- to -12-months data aid an 'inhibition of structural damage' label. Inevitably, more trials will be conducted in regions like Eastern Europe and Asia and away from historic markets like the US and Western Europe. Physicians believe that it has become increasingly difficult to recruit large patient numbers from the historic markets who fit into the stringent patient criteria needed to fulfil regulatory requirements. ------------------------------------------------------------ Full Report Details at - http://www.fastmr.com/ ------------------------------------------------------------ Your key questions answered * What are the ideal attributes required for a new therapy to compete with currently marketed treatments? * Which early stage rheumatoid arthritis targets show promise according to leading rheumatologist opinion? * Besides kinase inhibition, what are the other emerging therapeutic approaches for rheumatoid arthritis? * To what extent does clinical trial design impact the eventual drug labelling given to rheumatoid arthritis treatments? * How has the rheumatoid arthritis pipeline across all stages of development changed since 2010? Report Table of Contents: Executive Summary Strategic scoping and focus Datamonitor key findings Related reports OVERVIEW Catalyst Summary CLINICAL PIPELINE OVERVIEW Extensive 2011 pipeline demonstrates high commercial interest in rheumatoid arthritis Analysis by drug class highlights considerable focus on kinase inhibitors Growing interest in oral small molecules Late-stage development compounds recently discontinued dnaJP1 (AT-001; Adeona Pharmaceuticals) GLPG-0259 (Galapagos) CEP-37247 (ART621; Cephalon) RG4934 (Roche) ILV-095 (PF-05212368; TARGET PRODUCT PROFILE Methotrexate is considered the gold standard for rheumatoid arthritis Enbrel (etanercept; Target product profile versus current level of attainment Efficacy Safety Formulation Cost CLINICAL TRIAL DESIGN IN RHEUMATOID ARTHRITIS Proof of concept trials Clinical trials Clinical endpoints Health Assessment Questionnaire Other endpoints Future developments in clinical trial design Shift towards patient recruitment across multiple countries and away from the US and Western Europe Physicians desire and anticipate more head-to-head trials against tumor necrosis factor inhibitors INNOVATIVE EARLY-STAGE APPROACHES Kinase inhibitors are dominant in the early phase rheumatoid arthritis pipeline Ranking of key innovative therapeutic approaches in rheumatoid arthritis Kinase inhibitors, in particular JAK and Syk inhibitors are highly promising therapeutic approaches for RA Opinion leaders cite interleukin inhibitors as a promising approach for RA THE FUTURE OF TREATMENT IN RHEUMATOID ARTHRITIS Oral JAK inhibitor has potential to alter RA treatment landscape Biomarkers to predict response to biologic therapy Potential to combine therapies in future treatment of rheumatoid arthritis, but further investigation is needed BIBLIOGRAPHY Journal papers Websites Datamonitor reports APPENDIX A Physician sample breakdown The survey questionnaire APPENDIX B Contributing experts Conferences attended Report methodology About Datamonitor The Datamonitor Group is a world-leading provider of premium global business information, delivering independent data, analysis and opinion across the Automotive, Consumer Markets, Energy & Utilities, Financial Services, Logistics & Express, Pharmaceutical & Healthcare, Retail, Technology and Telecoms industries. Datamonitor's market intelligence products and services ensure that you will achieve your desired commercial goals by giving you the insight you need to best respond to your competitive environment. View more research from Datamonitor at http://www.fastmr.com/ About Fast Market Research Fast Market Research is an online aggregator and distributor of market research and business information. We represent the world's top research publishers and analysts and provide quick and easy access to the best competitive intelligence available. For more information about these or related research reports, please visit our website at http://www.fastmr.com or call us at 1.800.844.8156. # # # Fast Market Research is an online aggregator and distributor of market research and business information. We represent the world's top research publishers and analysts and provide quick and easy access to the best competitive intelligence available. End
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