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Central Nervous System (CNS) Compound Library from OTAVA
There are many different drug targets expressed in brain tissue. The delivery of drugs to central nervous system (CNS) is complicated by blood brain barrier (BBB) which controls entry of drugs into CNS.
OTAVA Ltd. offers CNS compound library which currently contains about 2 000 compounds. All the selected compounds possess physicochemical properties preferable for BBB penetration and they are simultaneously suitable for oral administration. Molecular weight of compounds selected ranges from 160 to 450, sum of oxygen and nitrogen atoms ≤ 5, number of rotatable bonds ≤ 8, CLogP > 0 and CLogD between 1 and 3. Parameter filters of CLogD and number of rotatable bonds restriction have the main influence on oral bioavailability. Biologically unstable compounds and compounds containing carboxyl groups, reactive groups or unwanted atoms were removed from this library.
CNS Targeted Library from OTAVA is designed as a special screening library containing compounds with high probability to penetrate blood brain barrier thus additional CNS permeability optimization for found inhibitors generally is not required. More information about this library you can find on our website
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OTAVA Ltd. is an international science-based chemical company founded in 1997. It has production laboratories and offices in Europe (Kiev, Ukraine) and North America (Toronto, Canada).