Clinical Trial Patient Recruitment: Accelerate Enrollment, Increase Retention and Reduce Costs

Oct. 30, 2010 - PRLog -- Clinical trial costs are skyrocketing amidst patient shortages, fewer drug approvals and limited growth in the number of available clinical investigators. At the same time, companies face stringent demands for more safety data — and patient recruitment stands as a pivotal roadblock. As pressure mounts and competition for patients intensifies, superior trial teams build resilient strategies for attracting and retaining patients, and their efforts are backed by sufficient resources.

Accelerate enrollment and expand your clinical capabilities with our detailed benchmarks and best practices from more than 80 companies across the life sciences. Use this report to eliminate barriers to patient recruitment and ensure trial completion:
•   Master trial recruitment: Explore 16 patient recruitment activities and track the effectiveness of each strategy. Learn how trial protocol can stimulate patient participation. Train site staff and investigators to emphasize recruitment.
•   Motivate patients to enroll: Learn how to think like a patient by mastering eight enrollment motivators — including both tangible and emotional draws. Effectiveness ratings for each motivator will guide your strategy as you mine patient demographics and market research to bolster recruitment.
•   Integrate recruitment into formal trial structure and process: Resolve disagreements quickly by determining patient recruitment ownership and strengthening strategic partnerships with vendors. Consider using the
expertise of a patient recruitment specialist.
•   Budget for patient recruitment: Are you spending enough on patient recruitment? Win increased funding with detailed spending benchmarks (including recruitment as a percentage of the total trial budget), site-specific budget data, and information for 10 therapeutic areas and medical devices.
TABLE OF CONTENTS :

13 Executive Summary
17 Study Methodology
18 Study Definitions
19 Profiled Companies
20 Patient Recruitment: Five Key Findings and Recommendations
27 Supporting Patient Recruitment with Increased Budgets
79 Integrating CRO Outsourcing with Internal Structure
80 Patient Recruitment Structure
84 Using a CRO to Assist with Patient Recruitment
88 Best Practices in CRO Contracting
95 Methods and Activities to Improve Patient Recruitment
97 Site and Patient Demographic Evaluation
107 Site Development
115 Mass Media Marketing
123 External Patient Recruitment Activities
131 Patient Motivators and Patient Retention
132 Patient Motivators
142 Patient Retention
155 Company Profiles
156 Oncology Trials
170 Type 2 Diabetes Trials
174 Obesity Trials
176 Cardiology and Thrombosis Trials
180 CNS/Neurology Trials
186 Mental Health Trials
190 Hematology Trials
192 Infectious Disease Trials
196 Pain Trials
198 Rheumatology Trials
200 Respiratory Trials
202 Medical Technology Trials
204 Consumer Products Trials
206 Other Trials

KEY METRICS
The five chapters in Clinical Trial Patient Recruitment include benchmarks that detail patient recruitment spending, structure, and activities, as well as data for patient enrollment motivators, recruitment tools and retention strategies.

Chapter 1: Supporting Patient Recruitment with Increased Budgets
(52 data charts)
Patient recruitment budget data for sponsors, sites and CROs broken out by trial phase (Phase 1, 2, 3a and 3b, and 4):
• Percentage of clinical trial budget dedicated to patient recruitment
• Dedicated patient recruitment budgets (trials and sites)
• Total trial budgets per phase at trial level and site-specific level
• Patient recruitment budgets per patient enrolled
Patient recruitment spending data broken out by therapeutic area:
• Cardiovascular
• Central Nervous System/Neurology
• Type 2 Diabetes
• Hematology
• Infectious Disease
• Inflammation
• Mental Health
• Oncology
• Pain
• Urology
• Medical Device/Diagnostic

Chapter 2: Integrating CRO Outsourcing with Internal Structure
(5 data charts)
• Prominence of recruiting outsourcing, including reasons sponsors contract with vendors for patient recruitment
• Popularity of dedicated patient recruitment groups
• Efforts to integrate patient recruitment into trial protocol design

Chapter 3: Methods and Activities to Improve Patient Recruitment
(31 data charts)
Data (including effectiveness rankings) for 16 patient recruitment activities:
• Evaluating site and investigators
• Conducting patient demographic/population research
• Working with advocacy groups
• Organizing health fairs and community outreach
• Training site staff/investigators on patient recruitment
• Developing site support materials
• Using Medical Science Liaisons (MSLs)
• Managing a call center
• Contacting patient referrals
• Managing mass media marketing:
• Radio
• Newspaper/print
• Television
• Web-based marketing

Chapter 4: Patient Motivators and Patient Retention
(21 data charts)
Effectiveness by phase for the following Patient Motivators:
• Prospect of improved treatment
• Convenience of sites
• Prospect of free medication/treatment
• Number/frequency of visits
• Short trial duration
• Transportation compensation
• Monetary compensation
• Non-monetary incentives
Percentage of companies using Patient Retention strategies, by phase and company type:
• Visit reminders by email
• Visit reminders by text message
• Print/paper patient support materials
• Online patient support materials
• Treatment follow-up by phone
• Follow-up by web/email
• Transportation assistance
• Patient visits
• Caregive support

Chapter 5: Company Profiles
(54 data charts)
Each profile contains the following information:
• Patient Recruitment Profile
• Trial information
• Therapeutic area
• Number of patients enrolled
• Trial status
• Company Information
• Company type
• Region
• Patient Recruitment Spending
• Presence/absence of dedicated budget
• Total trial budget
• Patient Recruitment Timeline
• Targeted enrollment vs. actual enrollment
• Months behind or ahead of schedule
• Patient Recruitment Tactics
• Patient recruitment activity
• Company performing task (e.g., sponsor, CRO, other vendor)
• Effectiveness ranking



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