Comet Assay IV at the forefront of cancer research

Aug. 2, 2010 - PRLog -- Shown below are findings from some recent papers using Comet assay IV (http://www.scorecomets.com) for scoring comet assay slides:

Investigations into Xanthohumol, a hop derived prenylated flavonoid found in beer, suggest that it protects against DNA damage induced by a common cooked food mutagen in rat colon mucosa and liver cells [1].

A small clinical study in healthy adult volunteers demonstrated that drinking green breakfast tea significantly reduces the genotoxic effects induced by artificial exposure to UVA/VIS radiation in peripheral blood cells [2].

Another study investigating the protective properties of Glucomannan has also generated some interesting results. The research suggests that the commonly used thickener and emulsifier has some protective effects on fecal water-induced DNA damage on Caco-2 cells, which are further enhanced by partial hydrolysis [3].

Research scientists rely on Comet Assay IV for reliable, reproducible and accurate measurements. You can find out more about Comet Assay IV on our dedicated comet assay website (http://www.scorecomets.com).

Many other white papers covering a broad range of topics were published this month using data generated by Comet Assay IV. View our comprehensive list of Comet Assay papers online (http://www.scorecomets.com/assay/#papers).

[1] Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ)
(2010) F Ferk et al, Mut. Res. (epub ahead of print)
[2] Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion
(2010) H Malhomme de la Roche et al, J.Photobiol. (article in press)
[3] Partial hydrolysis enhances the inhibitory effects of konjac glucomannan from Amorphophallus konjac C. Koch on DNA damage induced by fecal water in Caco-2 cells
(2010) Shu-Lan Yeh et al, Food Chem. 119(2):614-618

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