New Market Report: Preclinical Development of Monoclonal Antibodies and Related Biologicals

Recently published research from Business Insights, "Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates", is now available at Fast Market Research
Spread the Word
Listed Under

* Antibodies
* Monoclonal
* Preclinical
* Antibody
* Ctd
* Mabs
* Human
* Drug
* Therapeutic
* Platform

* Medical
* Research
* Biotech

* Massachusetts - US

April 30, 2010 - PRLog -- Monoclonal antibodies form the fastest growing segment of the pharmaceutical industry, with total annual sales expected to top $50 billion in the next four years. 23 full-size monoclonal antibodies and three monoclonal antibody fragments have been launched so far, several having quickly reached 'blockbuster status' (annual sales of over $1 billion). Between 1995 and 2007, the number of monoclonal antibody-based drug candidates entering clinical trials more than tripled, and this expansion is continuing.

This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.

The newest wave of drug candidates based on these technologies can be seen in more than 200 case studies, which identify every commercial company known to have carried out preclinical studies of therapeutic monoclonal antibodies in the last year. Finally, prospects and challenges for the future of this field are discussed, with opinions from scientific pioneers and industry leaders.

Key Features of this report

* Illustrated 'beginners guide' to monoclonal antibodies: What they are, how they are made and why they hold such great promise for the treatment of disease.
* More than 80 descriptions of proprietary technologies currently in use around the world to select, produce and re-engineer monoclonal antibodies.
* More than 30 original, full-color diagrams illustrating the science and technology of monoclonal antibodies, both as they appear in nature and in the myriad new forms now being assessed in preclinical trials.

Scope of this report

* Understand the basic qualities of monoclonal antibodies and how these qualities translate into unique medical and commercial features for drug candidates.
* Appreciate the challenges and risks of monoclonal antibodies, as well as their promise.
* Assess promising new technologies for investment or in-licensing.
* Identify which companies are involved in this field, and what they are doing.
* Predict the kinds of drug that will enter clinical trials in the next 1-4 years and may reach the market in the next 5-10 years.

Key Market Issues

* New monoclonal antibodies can be used to target new disease processes that are not currently addressed by any other therapies, thereby accessing market areas with high unmet demand.
* The inherent specificity and predictability of monoclonal antibodies have been shown to shorten drug development times and increase rates of success in preclinical and clinical trials, relative to non-biological 'small molecule' drugs.
* High barriers to entry currently prevent many new companies from entering this field. The techniques now used to create, select and modify monoclonal antibodies for human therapeutic use are protected by intellectual property, which the originators defend vigorously. However, several early patents on fundamental techniques will expire very soon.

Key findings from this report

* Early challenges relating to immunogenicity, tissue penetration, administration and production of monoclonal antibodies are being addressed by myriad new technologies.
* The competitive benefits of identifying and addressing new therapeutic targets continue to provide incentives for new target selection and monoclonal antibody identification programs.
* Established techniques for 'humanization' of non-human monoclonal antibodies remain popular, despite the rise of newer 'fully human' monoclonal antibody technologies. This may be due to the robust nature of the earlier technologies and/or the imminent expiries of key patents.
* Genetic engineering methods and novel 'host cell' production systems are being used to optimize and modify functions of monoclonal antibodies. Proprietary platforms using these methods have been widely licensed to many of the major players in the biopharmaceutical industry.

Key questions answered

* What are monoclonal antibodies, and what can they do?
* Why are so many companies developing them as therapeutic agents?
* Which companies are currently working to validate and develop the latest generation of drug candidates based on monoclonal antibodies?
* What technological and regulatory challenges face these companies in developing such candidates and bringing drugs to market?

For more information or to purchase this report, go to:

About Business Insights

Business Insights appreciate the importance of accurate, up-to-date incisive market and company analysis and their aim therefore is to provide a single, off-the-shelf, objective source of data, analysis and market insight. Business Insights work in association with leading industry experts to produce a range of reports across a wide range of industry sectors.  By working in association with so many experts they are able to provide clients with more incisive market analysis specific to the client's industry sector. No other market analysis company provides such focused and trusted market analysis, across such a wide range of industry sectors.  View more research from Business Insights at

About Fast Market Research

Fast Market Research is an online aggregator and distributor of market research and business information. We represent the world's top research publishers and analysts and provide quick and easy access to the best competitive intelligence available.

For more information about these or related research reports, please visit our website at or call us at 1.800.844.8156.
Email:*** Email Verified
Tags:Antibodies, Monoclonal, Preclinical, Antibody, Ctd, Mabs, Human, Drug, Therapeutic, Platform
Industry:Medical, Research, Biotech
Location:Massachusetts - United States
Account Email Address Verified     Account Phone Number Verified     Disclaimer     Report Abuse
Fast Market Research News
Daily News
Weekly News

Like PRLog?
Click to Share