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Follow on Google News | Genetic Engineering and Biotechnology News (GEN) Reports on Mass Spec in Drug DiscoveryMass spectrometry driven by a broad range of improvements in hardware and software technologies has given rise to an increasing number of applications in the clinic, according to an article in Genetic Engineering and Biotechnology News (GEN).
E-mail: jsterling@genengnews.com Genetic Engineering and Biotechnology News (GEN) Reports on Mass Spec in Drug Discovery NEW ROCHELLE, NY—Mass spectrometry, driven by a broad range of improvements in hardware and software technologies, has given rise to an increasing number of applications in the clinic, according to an article in the May 15 issue of Genetic Engineering and Biotechnology News (GEN) (http://www.genengnews.com) “Biomarker discovery has become a major trend for new drug discovery and development,” Researchers at the Fred Hutchinson Cancer Research Center, for example, are working to discover cancer biomarkers using patient plasma samples. The proteins that really reflect disease development are low-abundance proteins, which are below the nanogram/mL level. To detect these rare proteins, Dr. Wang’s group uses chromatogram- Perhaps even more difficult to analyze than plasma, cerebral spinal fluid (CSF) poses different challenges. Fundamental studies, like others have done with plasma, need to be carried out to understand the nature of interfering compunds. At Lundbeck Research USA, triple quadrupole MS-MS is used to analyze CSF samples because it is the best way to do quantitative analysis in complex matrices. Also covered in the GEN article is MS research in drug discovery taking place at Merck, Expression Pathology, Caprion Proteomics, and Wyeth. For a copy of the May 15 issue of GEN, please call (914) 740-2122 or e-mail ebicovny@liebertpub.com Genetic Engineering and Biotechnology News (http://www.genengnews.com), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics. Website: www.liebertpub.com End
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