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Follow on Google News | Abdominal Aortic Aneurysm(AAA) Proteomics Research & Hemoglobin Depletion Using HemogloBind™By: Biotech Support Group "Conditioned mediums from AAA were incubated with HemogloBind™ HemogloBind™ High CD163+ macrophages in AAA adventitia wall picks up hemoglobin. High hemoglobin content and high CD14++CD16++CD163++ CD163 on the surface of monocytes and tissue macrophages scavenges hemoglobin mainly in the Hb-derived iron rich AAA adventitia. CD163 causes less hemoglobin concentration, high heme oxygenase biosynthesis, interleukin -1 release, high CD163 and HLA-DR expression. Hemoglobin causes high monocyte chemotaxis in AAA samples. Adding conditioned medium also increases monocyte migration. Hb or AAA conditioned medium may induce chemotaxis by Hb-CD163 interactions whereas adding CD163 blocking antibody inhibits hemoglobin uptake and sustains hemoglobin concentration. AAA pathology consists of a pulsating enlargement or tender mass on ultrasound, CT scan, MRI or angiogram often requiring open surgical repair or endovascular repair. Hemoglobin causes inflammation and oxidation. Macrophages pickup hemoglobin from hemolysis & during wound healing. CD163 macrophages take up hemoglobin in adventitia of abdominal aortic aneurysm. CD163 functions on endocytosis of haptoglobin- Sample preparation allows research on hemoglobin-based oxygen carriers, hemoglobin polymerization, pathovascular remodeling of AAA mural thrombus, CD163 mRNA expression, protein expression, monocyte recruitment and CD163 dependent monocyte chemotaxis. “We are pleased with this data on abdominal aortic aneuryism & hemoglobin proteomics. HemogloBind™ About Biotech Support Group LLC Biotech Support Group LLC is a leading provider of proteomic, metabolomic and genomic sample preparation and enrichment products and services. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin depletion, Cleanascite™ Contact: Dr. Swapan Roy & Matthew Kuruc Biotech Support Group LLC 1 Deer Park Drive, Suite M Monmouth Junction NJ 08852 732-274-2866 Worldwide 800-935-0628 North America sales@biotechsupportgroup.com http://www.biotechsupportgroup.com Reference: Rubio-Navarro, Alfonso, et al. "Hemoglobin induces monocyte recruitment and CD163-macrophage polarization in abdominal aortic aneurysm." International Journal of Cardiology (2015). http://www.internationaljournalofcardiology.com/ End
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