NEW BIONET 2nd Generation Premium Fragment Library

CAMELFORD, U.K. - June 30, 2015 - PRLog -- Key Organics Limited is a Leading Provider of Chemistry Services, Analytical Services and BIONET Fragments, Screening Compounds and Biochemical’s to the global Life Science industries

A 2nd generation BIONET Premium Fragment Library has been constructed in collaboration with the Center for the Development of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA  02142 and NMX Research and Solutions Inc., 500 Cartier Blvd., Suite 6000, Laval, Québec, Canada H7V 5B7.

Key Features and Benefits:

1166 compounds with experimentally assured aqueous solubility in PBS buffer.

Excludes fragments deemed to aggregate as determined by 1H NMR spectra

1H NMR pdf and raw data files provided for all compounds purchased

Chemical shifts provided for all compounds in an excel file.

Strictly meet Astex Rule of 3 including polar surface area ≤ 60 and number of atoms ≤ 16

Includes 445 fragments found in approved drugs and >1100 sharing cores found in drugs

Filtered  to exclude promiscuous and reactive substructures

The following data package will be supplied for each aqueous soluble fragment purchased:

Aqueous buffer 1H NMR pdf

Aqueous buffer 1H NMR raw data file

1H NMR chemical shifts supplied in an excel file

Provision of this data will enable practitioners to rapidly build fragment pools and initiate screening.

The BIONET Premium Fragment library is available in milligram or micromolar quantities. Cherry picking is available.