A Paper on ITE Promoting Cancer Cell Differentiation Has Been PublishedAhR Pharmaceuticals Announces a Joint Publication of a Scientific Paper in Nature Communications with a Science Team at Zhejiang University
ITE is an endogenous ligand or natural hormone for the aryl hydrocarbon receptor (Ah receptor or AhR). Once binding to the receptor, ITE activates and drives the hormone-receptor complex in mediating a series of important biological and pharmacological processes in the body. Evidences collected by scientists from AhR Pharmaceuticals and a global research community as well have demonstrated ITE’s potentials in treating cancer, obesity, and disorders related to imbalanced actions of immune systems. The paper revealed a molecular mechanism on how ITE promotes differentiation of cancer cells or cancer stem cells by stimulating its receptor, the Ah receptor, to bind to the promoter region of Oct4 gene and then reduce the production of its gene product. Oct4 inhibits differentiation and reducing the production of Oct4 can, therefore, promote the differentiation process. “It has been known to the field for a couple of decades that the Ah receptor can induce cell differentiation,” The paper is entitled “Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells”. Leading the research efforts of AhR Pharmaceuticals’ For more information on AhR Pharmaceuticals, Inc., its technologies, and research activity, please visit www.ahrpharma.com. For more information on Zhejiang University, please visit www.zju.edu.cn. A related news story in Chinese published by the Zhejiang University official website is accessible through this link: http://www.news.zju.edu.cn/ End
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