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Follow on Google News | A Ranking of Environmental ChemicalsBy: Austrian Science Fund FWF In our daily lives we are exposed to a great variety of environmental chemicals found in cleaning substances, cosmetics, plastic products, textiles or food supplements. Many of these synthetic products leave traces in our bodies and are known to have an impact on our immune system, hormonal balance or cardio-vascular system. Within the context of the European Union's REACH programme and the US National Toxicity Programme, chemicals are systematically screened for their potentially harmful impact. The pharmacist Daniela Schuster is developing methods designed to vastly improve the efficiency and precision of these tests. In her work at the Institute of Pharmacy at the University of Innsbruck, the researcher benefits from her experience with drug discovery and development applying the methods used in this field. Simulation of effects and side effects In order to investigate the action mechanisms in chemicals, Schuster developed so-called pharmacophore- Hormone focus shows first results Together with her team and international partners, Daniela Schuster is developing a screening platform based on the principle of the "pharmacophore model" in an ongoing FWF project. The individually built models are cross-checked against databases that list environmental chemicals. The screening enables the scientists to identify potentially toxic "candidates" The researchers in this new project derive high expectations from the fact that their tests involve enzymes responsible for hormone production whose potentially harmful effects have hardly ever been investigated so far. "We already have some very interesting results", reports Schuster from the ongoing project. "It has been shown, for instance, that parabens impede oestrogen degradation. This means they could foster the growth of oestrogen-dependent tumours", explains the scientist. Parabens are preservatives often used in cosmetics, but additionally in food. "We have also discovered some vanillin derivatives that can increase the oestrogen level", Schuster adds. This type of flavouring substance is found in chewing gum, for instance. According to Schuster, the first tests of the pilot study showed that some food colourings also had the potential to influence the oestrogen level. Prediction platform enhances safety The computer-based early warning system developed by the researchers from Innsbruck has the advantage of enabling experts to work in a more targeted manner and perform more tests. Apart from the early warning system for potentially dangerous substances, the system will also be able to list compounds that have turned out to be harmless. "We use an exclusion procedure, which means we can wave the harmless ones through quite quickly. That is an advantage of the computer model in combination with the lab tests", emphasises Schuster. Above all, the method is an important tool for the future so as to enable additional predictions to be made. The screening platform the team developed and the case studies generated on this basis are to lay the foundations for further systematic studies. "It would be desirable to have more comprehensive official regulations about which tests need to be performed in order for chemicals to be accepted as safe", says Schuster about one goal she is pursuing with her basic research. Prior to that, however, the relevance for the human body of the individual mechanisms has to be identified, and the number of candidates here is huge. Personal details Daniela Schuster (http://www.uibk.ac.at/ Image and text available from 10 am CEST on Monday, 4 May 2015, at: http://www.fwf.ac.at/ Scientific Contact: Dr. Daniela Schuster University of Innsbruck Innrain 80/82 6020 Innsbruck, Austria T +43 / 512 / 507 - 58253 E daniela.schuster@ W http://www.uibk.ac.at Austrian Science Fund FWF: Marc Seumenicht Haus der Forschung Sensengasse 1 1090 Vienna, Austria T +43 / 1 / 505 67 40 - 8111 E marc.seumenicht@ W http://www.fwf.ac.at Distribution: PR&D – Public Relations for Research & Education Mariannengasse 8 1090 Vienna, Austria T +43 / 1 / 505 70 44 E contact@prd.at W http://www.prd.at End
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