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Is Duloxetine More or Less Effective Than Fluoxetine in Children and Teens with MDD?


 
 
JCAPv24n3
JCAPv24n3
PRLog - May 19, 2014 - NEW ROCHELLE, N.Y. -- Two studies of the anti-depressive drug duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), compared its effectiveness and safety to either fluoxetine or placebo in children and adolescents with major depressive disorder (MDD). The results of these first controlled trials of duloxetine in pediatric patients with MDD are published in Journal of Child and Adolescent Psychopharmacology (http://www.liebertpub.com/cap (http://www.liebertpub.com/cap)), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com (http://www.liebertpub.com)). The articles are available free on the Journal of Child and Adolescent Psychopharmacology (http://www.liebertpub.com/cap (http://www.liebertpub.com/cap)) website.

Graham Emslie, MD and coauthors evaluated the efficacy and safety of a fixed dose of duloxetine—either 60 mg or 30 mg once a day—versus 20 mg daily of fluoxetine or placebo in children ages 7-11 years and adolescents ages 12-17 years. In the article “A Double-Blind Efficacy and Safety Study of Duloxetine Fixed Doses in Children and Adolescents with Major Depressive Disorder (http://online.liebertpub.com/doi/full/10.1089/cap.2013.0096)” they compare the treatments based on worsening of suicidal ideation, emergence of suicidal behavior, and adverse effects including abnormal findings on an electrocardiogram and laboratory tests.

Sarah Atkinson, MD and colleagues compared a flexible dosing regimen of duloxetine (60-120 mg daily) to fluoxetine (20-40 mg daily) or placebo and reported measures from a depression rating scale and a suicide severity rating scale, as well as treatment-related adverse events, in the article “A Double-Blind Efficacy and Safety Study of Duloxetine Flexible Dosing in Children and Adolescents with Major Depressive Disorder (http://online.liebertpub.com/doi/full/10.1089/cap.2013.0146).”

Neither study found a significant difference in response between the two drugs and placebo. The authors suggest that this may be due to the complexity of these novel studies and offer observations that may direct the design of future investigations.

“Drs. Emslie and Atkinson and their colleagues took a fascinating approach towards testing the efficacy of a novel SNRI in the pediatric population,” said Harold S. Koplewicz, MD, Editor-in-Chief of Journal of Child and Adolescent Psychopharmacology, and President, Child Mind Institute, New York, NY. “Researchers are of course excited by positive results, but in this case the curious lack of response tells us volumes about how to better design complex studies—studies that may soon give us uncommon insight into our pharmacologic interventions.”

About the Journal
Journal of Child and Adolescent Psychopharmacology (http://www.liebertpub.com/cap) is an authoritative peer-reviewed journal published 10 times a year online with Open Access options and in print. The journal is dedicated to child and adolescent psychiatry and behavioral pediatrics, covering clinical and biological aspects of child and adolescent psychopharmacology and developmental neurobiology. Complete tables of content and sample issue may be viewed on the Journal of Child and Adolescent Psychopharmacology (http://www.liebertpub.com/cap) website.

About the Publisher
Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com) is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cyberpsychology, Behavior, and Social Networking and Games for Health Journal. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com) website.


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Tags:psychopharmacology, Major Depressive Disorder, Duloxetine, fluoxetine, Harold Koplewicz
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