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Research Article Cites HemogloBind™ to Improve Efficiency of Cholinesterase Analysis


 
 
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biotechsupportgroup_hemoglobindhemoglobinproteomic
PRLog - Jan. 12, 2014 - MONMOUTH JUNCTION, NJ -- Biotech Support Group reports on a recent research article which describes the simplicity and efficiency of their proteomic sample preparation technology for hemoglobin depletion. The citation is:

McGarry, K., Bartlett, R., Machesky, N., Snider, T., Moyer, R., Yeung, D. and Brittain, M. Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis. Advances in Bioscience and Biotechnology (2013) 4, 1020-1023. http://dx.doi.org/10.4236/abb.2013.412136

Acetylcholine is an essential neurotransmitter, and inhibitors of cholinesterases(ChEs) are potent toxins. In a widely used enzymatic assay for evaluating ChE activity (Ellman et al), the presence of hemoglobin creates a substantial spectrophotometric background that interferes and must be overcome in order to accurately monitor cholinesterase activity from whole blood. In this article, a classical method was compared to a sample prep treatment incorporating HemogloBind™, Biotech Support Group’s unique solid-phase polymer for hemoglobin depletion. It was demonstrated that pretreatment of blood samples with Hemoglobind™ was a cost effective, high-throughput sample preparation alternative for obtaining total ChE activity and comparable to the classical method which involves separating plasma from red blood cells by centrifugation, lysing, and repeated washing of the cell membranes. With the latter classical method, preparing membranes prior to analysis is labor intensive and slow and removes plasma activity so total blood level activity cannot be efficiently assessed.

“We continue to focus our product development on the dual problems associated with high abundance proteins and retention of functional integrity. This article further validates our unique surface technology approach, not based on antibodies or engineered bio-ligands, as being highly selective and an efficient method for the depletion of hemoglobin concurrent with the recovery of functional activity” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

About Biotech Support Group LLC

Biotech Support Group LLC is a leading developer of proteomic and genomic sample preparation and enrichment products. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ & ProPrep™ for nucleic acid isolation. For more information, go to http://www.biotechsupportgroup.com

Contact:

Matthew Kuruc
Biotech Support Group LLC
1 Deer Park Drive, Suite M
Monmouth Junction NJ 08852
732-274-2866 Worldwide
800-935-0628 North America
www.biotechsupportgroup.com

Reference:

McGarry, K., Bartlett, R., Machesky, N., Snider, T., Moyer, R., Yeung, D. and Brittain, M. Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis. Advances in Bioscience and Biotechnology (2013) 4, 1020-1023. http://dx.doi.org/10.4236/abb.2013.412136

Contact
Biotech Support Group
732-274-2866
***@biotechsupportgroup.com

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Source:Biotech Support Group
Location:United States
Industry:Biotech, Medical
Tags:Hemoglobin, proteomics, enzymatic assay, blood products
Shortcut:prlog.org/12266575
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