"We are excited to provide drug discovery and toxicology scientists a powerful new platform implementing a wide variety of predictive PK techniques, and which doesn't depend on black-box proprietary models," said Director of acslX Product Development Conrad Housand. "This release is the culmination of over two years of collaboration, development and testing, and we look forward to incorporating even more capabilities in the coming months."
Current ADME Workbench capabilities include:
·Support for several state-of-the-
·PBPK models which include advanced multi-compartment GI uptake models, support for both linear and nonlinear kinetics, and an advanced liver model
·Support for end-user customization of any of the provided PBPK models
·A choice of prediction methods depending on availability of preclinical data determined either in vitro and/or in vivo in single or multiple species
·Ability to integrate values of ADME parameters predicted from a broad range of methods
·Ability to simulate a single compound or multiple compounds in batch mode
·Simulation of tissue concentration at the macro level (whole organ) and micro level (cell, interstitial fluid) either for the bound or unbound drug condition
About AEgis Technologies
AEgis Technologies is a privately held small business headquartered in Huntsville, Alabama, USA, that provides advanced technology and expert consulting services to industries throughout the world. AEgis specializes in modeling & simulation (M&S) and micro/nanoscale technology development. The company’s M&S products and services include software for the pharmaceutical/
AEgis has enjoyed steady growth with revenues increasing to $65 million in sales and employment of 325+ professionals. AEgis has been instrumental in the acceptance of M&S as a profession, as a graduate program of study among many colleges and universities and in the creation of an M&S standards and professional certification across the international M&S professional community-of-
AEgis corporate headquarters are located at 410 Jan Davis Drive, Huntsville, AL 35806; Tel: 256-922-0802;
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acslX and ADME WorkBench are a trademarks of The AEgis Technologies Group, Inc.