What Role do Processing Bodies Play in Cell Survival and Protection against Viral Infection?

NEW ROCHELLE, N.Y. - May 16, 2013 - PRLog -- New Rochelle, NY—As scientists learn more about processing bodies (PBs), granules present within normal cells, they are unraveling the complex role PBs play in maintaining cellular homeostasis by regulating RNA metabolism and cell signaling. Emerging research is revealing how virus infection alters PBs to enhance viral replication and how, in turn, PBs are able respond and limit a virus's ability to reproduce. This novel mechanism allows PBs to contribute to the body's immune defenses, as described in an article in DNA and Cell Biology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the DNA and Cell Biology website at liebertpub.com/dna.

Asit Pattnaik and Phat Dinh, University of Nebraska-Lincoln, explore the growing knowledge base on PBs and their components, and how they interact with viruses. The authors review the literature and discuss the positive and negative consequences of PB-virus interactions and the potential implications of the role of PBs in RNA processing, cell signaling and survival, and immune function.

In the article "Manipulation of Cellular Processing Bodies and Their Constituents by Viruses," Pattnaik and Dinh describe the mechanism by which viruses may alter the composition of the PBs to benefit viral RNA replication at the expense of host cell homeostasis.

"This brief review highlights one of many important cellular processes that are subverted by viral infection," says Carol Shoshkes Reiss, PhD, Editor-in-Chief, Departments of Biology and Neural Science, New York University, NY. "The sequestration of RNA in the cytoplasm is an under-appreciated regulatory pathway."  

About the Journal
DNA and Cell Biology is the trusted source for authoritative, peer-reviewed reporting on the latest research in the field of molecular biology. By combining mechanistic and clinical studies from multiple systems in a single journal, DNA and Cell Biology facilitates communication among biological sub-disciplines. Coverage includes gene structure, function, and regulation; molecular medicine; cellular organelles; protein biosynthesis and degradation; and cell-autonomous inflammation and host cell response to infection. Complete tables of content and a sample issue may be viewed on the DNA and Cell Biology website at liebertpub.com/dna.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Human Gene Therapy, Antioxidants & Redox Signaling, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s more than 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website at liebertpub.com.

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