The CytoPatch™: Faster, Cheaper, and More Powerful

PRLog (Press Release) - Mar. 4, 2013 - (Rostock) – Germany, March 4th, 2013.  The CytoPatch2 builds on the technical success of the original CytoPatchTM system and is the first fully automated patch clamp system that is a viable alternative to manual patch clamp.  Designed to closely mimic manual patch clamp processes, the CytoPatch2 generates the same high quality data as an experienced electrophysiologist working manually, and offers the broadest range of protocol flexibility of any available automated patch clamp system, making it ideal for researchers interested in ion channel biophysical characterisation and pharmacology.  

Because the CytoPatch2 matches manual patch clamp with respect to data quality, users can fully benefit from the three R’s of automation without compromise.  Reproducibility of data quality is gained by taking human subjectivity out of the patch process, Robustness of an assay is improved with the CytoPatch2 monitoring every step in the patch process and ensuring user-definable quality control criteria are met, and Reliability of the process is ensured by the fully integrated nature of the system components in the CytoPatch2.  Additionally, by recording from two cells simultaneously, the CytoPatch2 offers double the throughput compared to manual patch clamp, and combined with walk-away operation, the addition of the CytoPatch2 into any patch clamp laboratory guarantees a significant increase in productivity.  

By combining the microfluidic Cytocentering technology with a sophisticated liquid handling system and an all new digital amplifier with both voltage- and current clamp capabilities, the CytoPatch2 can record whole cell and single channel currents, and works equally well for voltage gated ion channels (constant perfusion mode) and ligand gated ion channels (fast solution exchange,

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