White Paper: Better Crystallization through Optimized Seeding

Feb. 11, 2013 - PRLog -- The new best practice white paper from METTLER TOLEDO explores how the optimization of crystallization seeding using in situ, real-time process feedback helps create desired final particle properties for better performing, more consistent fine chemical, pharmaceutical and bulk-chemical powders.

METTLER TOLEDO is pleased to announce the publication of the latest installment in its thought-leading white paper series. This free, downloadable paper entitled "Recent Advances for Seeding a Crystallization Process: A Review of Modern Techniques" explores crystallization experiments that, coupled with advanced seeding techniques and real-time in situ process feedback, provide results which significantly improve yields and reduce manufacturing costs.

Seeding has become a critical and widely-used step to optimize crystallization behavior, process efficiency, and product quality. However, a non-ideal seeding protocol can result in inconsistent filtration rates, drying times, yields, bulk density, flow properties and particle size distribution-any of which can disrupt downstream processing, potentially resulting in costly rework or even expensive product loss.

The addition of in situ particle monitoring helps researchers choose optimal seeding conditions based on parameters such as temperature, mass, and particle size distribution. In reported experiments, heightened process control helped establish efficient, repeatable crystallization processes that achieved important goals such as more predictable manufacturing outcomes, purer products, enhanced consumer safety, and lower overall production expenses.

The white paper details both general seeding theory and use of inline particle measurement tools such as Focused Beam Reflectance Measurement (FBRM), Particle Vision and Measurement (PVM), and ATR-FTIR (ReactIR) which allowed real-time process monitoring. Results include significantly improved fine particle counts which eliminated the need for post-crystallization milling. In practical application, this benefit has been shown to shorten production schedules for faster time-to-market,an essential ingredient in cost-effective chemical and pharmaceutical manufacturing in today's highly competitive global marketplace.

For more detail on how optimized seeding can help produce the kind of crystallization results that reduce manufacturing costs, enhance results, and improve safety, download the white paper free at http://us.mt.com/us/en/home/supportive_content/White_Pape...

About Mettler Toledo:
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.

Contact information:
Mettler-Toledo International Inc.
Im Langacher,  Zip Code 8606
Greifensee, Switzerland
E-Mail    : ePublicRelations@mt.com
Phone     : +41-44-944 33 85
Website  : www.mt.com