BioVision Introduces Two New Assay Kits Granzyme B Activity & Granzyme B Inhibitor Screening Kit

PRLog (Press Release) - Jan. 30, 2013 - Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates); Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. Granzyme B acts at multiple points to initiate the death of the offending cell. Studies of the granzyme B death receptor and internal signaling pathways may lead to critical advances in cell transplantation and cancer therapy.

Granzyme B Activity Assay Kit [Cat # K168-100 (100 Assays)]: In BioVision’s Granzyme B Activity Assay Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500 nm.

Key Features and Benefits of the Kit
- Simple & Sensitive
- Rapid, Reliable & Accurate
- Fluorometric quantification (Ex/Em = 380/500 nm)
- Measure Granzyme B activity in various biological samples or purified Granzyme B
- Kit provides ample reagents to perform 100 assays in a 96-well plate format

For more information, please visit, http://www.biovision.com/granzyme-b-activity-assay-kit-60...  

Granzyme B Inhibitor Screening Kit [Cat # K169-100 (100 Assays)]: In BioVision’s Granzyme B Inhibitor Screening Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500 nm. In the presence of potent Granzyme B Inhibitor, the hydrolyzation of substrate will be impeded. Inhibitor control, Ac-IEPD-CHO is included to compare the efficacy of test inhibitors.

Key Features and Benefits of the Kit
- Simple and Reliable
- Rapid, Convenient and High-Throughput Suitable
- Fluorometric (Ex/Em = 380/500 nm) quantification
- Screen/characterize/study Granzyme B inhibitors
- Kit provides ample reagents to perform 100 assays in a 96 well plate format

For more information, please visit, http://www.biovision.com/granzyme-b-inhibitor-screening-k...