Most cancer researchers would likely agree that not understanding how cancer develops is a major obstacle in the ongoing "war on cancer." However, in some scientists' minds the mechanism that underlies tumor development is not settled science. Under the Somatic Mutation Theory, cancers arise as a consequence of changes to DNA, while the Tissue Organization Field Theory states that they result from disruptions in normal cell communication needed to correctly form tissues. The initial debate explores these two major theories of cancer development in Disruptive Science and Technology, and the articles are available free on the Journal website at http://www.liebertpub.com/
Stuart Baker, ScD, National Cancer Institute (Bethesda, MD), initiates the debate with the article, "Paradoxes in Carcinogenesis Should Spur New Avenues of Research: An Historical Perspective."
Vincent Wilson, PhD, Louisiana State University (Baton Rouge, LA), emphasizes that cancer develops as a result of both genetic and environmental factors in “Carcinogenesis as the Sum of Its Parts.” Regardless of the specific causative event, multiple changes are required for an individual cancer cell and a tumor to develop. He suggests either combining the two main proposals for the mechanism of carcinogenesis, or subdividing cancer into subgroups developing specific hypotheses to explain the cause of each type.
Eric Lagasse, PharmD, PhD, University of Pittsburgh School of Medicine (PA), argues in “Battling Cancer: In the End What Matters the Most?” that while the initial event resulting in cancer is not yet clear, pointing out yet another cancer formation theory (Cancer Stem Cell Theory), cancer treatment can be improved by tailoring therapy to target the genetic characteristics of a patient's most aggressive tumor cells and to continue to monitor and modify treatment as needed to overcome drug resistance.
“The mechanisms underlying cancer formation are complex and not completely understood, even after some victories in the ‘war on cancer,’” says Editor-in-Chief Alan J. Russell, PhD, Highmark Distinguished Career Professor, Carnegie Mellon University, Pittsburgh, PA. “Drs. Baker, Wilson, and Lagasse present different points of view as to the most likely explanations for carcinogenesis. A deeper understanding of cancer mechanisms is important for designing therapeutics and formulating new research questions.”
Contact: Alan J. Russell, PhD
Highmark Distinguished Career Professor, Carnegie Mellon University
(914) 740-2100, alanrussell@
For more information on each article, please contact:
Paradoxes in Carcinogenesis Should Spur New Avenues of Research: An Historical Perspective
Contact: National Cancer Institute Press Office, ncipressofficers@
Carcinogenesis as the Sum of Its Parts
Contact: Louisiana State University Office of Communications and University Relations, firstname.lastname@example.org, (225) 578-8654
Battling Cancer: In the End What Matters the Most?
Contact: University of Pittsburgh Office of Public Affairs, (412) 578-9193
For more information about the publisher or the journal please contact:
Sophie Mohin, Mary Ann Liebert, Inc., publishers, email@example.com, (914) 740-2254
About the Journal
Disruptive Science and Technology, a breakthrough, highly innovative, peer-reviewed journal spearheaded by Editor-in-Chief Alan J. Russell, PhD, Highmark Distinguished Professor, Carnegie Mellon University, cultivates, harnesses, and explores how existing paradigms can be changed to improve human health, well-being, and productivity. The Journal provides a multimedia platform and forum for ideas and opportunities, promotes breakthrough science and engineering, facilitates the innovator-market relationship, and accelerates the transition from bench to society. Bold, transparent, and resistant to limitations driven by protection of the science and engineering status quo, Disruptive Science and Technology provides the first destination for those seeking to publish game-changing results that have the capacity to alter the way we live. For complete journal details, please visit the Disruptive Science and Technology website at http://www.liebertpub.com/
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative journals in many promising areas of science and biomedical research, including Tissue Engineering, Rejuvenation Research, and Environmental Engineering Science. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s more than 70 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website at http://www.liebertpub.com.