Introduction for Ampoule bottles’ Headspace Analysis Detection Methods

Dec. 31, 2012 - PRLog -- Ampoule bottle’s headspace analysis (especially the residual oxygen analysis ) related to the quality stability of powder-injection, water injection, infusion bottle and oral liquid in product warranty period. Through Labthink’s HGA-01 Headspace gas analyzer and its dedicated sampler can conveniently and efficiently solve the residual oxygen detection problem and make small-volume ampoule bottle and other packaging detecting achieve good result.

1.Why we must control ampoule bottle’s residual oxygen content of the headspace gas

Oxygen is the main factor to influence the product warranty period of powder injection, water injection and oral liquid. It was found that by control the gas proportion of the packaging can effectively prolong the product shelf life or improve the reservation quality. Nowadays some products’ packages such as powder injection, water injection and oral liquid, mainly adopt ampoule bottle’s packaging way.  After filling there will be a little gas remaining in the bottle, So the actual gas composite in the package bottle is different from expected, which take some difficulty in analyzing product quality, expected validity of warranty life and rationality of the packaging design .By HGA-01 Headspace Gas Analyzer produced by Labthink can effectively solve the gas composition problem in ampoule bottle. Now it had become an important means to check the drug design’s quality and one of the important ways to verify the product warranty.

2. Detecting difficulties in ampoule bottle’s Headspace gas analysis

Residual oxygen is an important point in headspace gas analysis, but the integral volume of common ampoule bottle package such as powder injection, water injection and oral liquid is small, and the headspace gas volume of ampoule bottle is less. The common headspace analyzing equipment can’t carry the analyzing test of gas collection amount which is less than 0.5ml and 0.2ml.And this is also the detecting difficulty of headspace gas analyzer for small volume packaging such as ampoule bottles.

3. Choose the appropriate Headspace Gas Analyzer HGA-01

Now some headspace gas analyzer on the market basically cannot complete the residual oxygen analysis of water injection and powder injection and other medicine.HGA-01 Headspace Gas Analyzer produced by Labthink can solve the above difficulties through the specialized sampler, which can make small package headspace gas analysis detection realized.HGA-01 Headspace Gas Analyzer absorb the advantage of desktop and portable equipment, and also have many unique advantages. Firstly, It can test oxygen and dioxide simultaneously, while the range and accuracy reach to the first-class in the international world. Secondly, it has annual and automatic operating mode and test oxygen and dioxide in the meantime.

Configure dedicated needle，gaskets and filters, get great improvement in exhaust time and response time ,which can totally ensure the reality and effectiveness of the testing data.
In addition, the instrument is equipped with the current international mainstream gas analyzer sensors, which can guarantee six years normal use. To facilitate the instrument have the portable and  hand function, and have the printing function which the traditional equipment don’t have ，which can make it conveniently used in various environments and have rapid detection for the sample.

4. Ampoule bottle residual oxygen analysis detection summary

The detection analysis for the headspace gas residual oxygen can make us control the packaging change of internal gas component for powder-injection, water-injection and oral liquid more conveniently, accurately and rapidly, and also the important data support for analysis of product quality, effectiveness of shelf life and rationality of packaging design and be an essential testing ways to strengthen the product quality control, the practical and reliable HGA-01 Headspace Gas Analyzer with dedicated procurement sampler equipment is the basis to have residual analysis control for more pharmaceutical companies.

More about the detailed information for pharmaceutical headspace gas analyzer, pls contact Emily for 0531-85060139 or go on the web: http://www.labthink.cn/en/ for inquiry.