Buy SERS Substrate for High Speed and Best Quality Raman Signal Detection

Uniform and highly SERS active substrates composed of silver (Ag) nanoparticles arrays with sub-5 nm gap. Transparent substrates, for Raman imaging of bacteria, are also available. Our SERS substrates offer stable and highly reproducible signals.
By: MA-tek Inc. Taiwan
 
Dec. 17, 2012 - PRLog -- ♦ Best quality SERS substrates available for purchase

Taiwan Patented Technology  for SERS substrates. Customers can order transparent or opaque SERS substrates. For Raman active species, Raman signal enhancement is about 10E6.  

Please contact:  MA-tek Inc., Taiwan, Republic of China.  
Company website: www.ma-tek.com
For online order, please write email to:  sales@ma-tek.com

To illustrate scientific and technological impact of our Raman substrates, please consider reviewing following papers.

Fabrication of SERS Substrates:
SERS substrates have been fabricated using Ag nanoparticle arrays with unprecedented small tunable gaps. The dependence of the enhancing capability of the substrate on the gap size provides quantitative evidence for the collective SERS effect and confirms predictions of interparticle-coupling-induced.
Ref: Advanced Materials, vol. 18, page 491, and year 2006.  

High Speed Detection of Changes in Bacterial Cell Walls:

Rapid and accurate diagnosis for pathogens and their antibiotic susceptibility is critical for controlling bacterial infections. Conventional methods for determining bacterium’s sensitivity to antibiotic depend mostly on measuring the change of
microbial proliferation in response to the drug. Such ‘‘biological assay’’ inevitably takes time, ranging from days for fast growing bacteria to weeks for slow-growers. Here, a novel tool has been developed to detect the ‘‘chemical features’’ of bacterial cell wall that enables rapid identification of drug resistant bacteria within hours. The surface-enhanced Raman scattering (SERS) technique based on our newly developed SERS-active substrate was applied to assess the fine structures of  the bacterial cell wall. The SERS profiles recorded by such a platform are sensitive and stable, that could readily reflect different bacterial cell walls found in Gram-positive, Gram-negative, or mycobacteria groups. Moreover, characteristic changes in SERS profile were noticed in the drug-sensitive bacteria at the early period (i.e., ,1 hr) of antibiotic exposure, which could be used to differentiate them from the drug-resistant ones. The SERS-based diagnosis could be applied to a single bacterium. The high-speed SERS detection represents a novel approach for microbial diagnostics. The singlebacterium detection capability of SERS makes possible analyses directly on clinical specimen instead of pure cultured bacteria.
Ref: PLOS One, Vol. 4, Issue 5, e5470, year 2009.

Functionalized Raman Substrates for Biological Studies:

Detecting bacteria in clinical samples without using time-consuming culture processes would allow rapid diagnoses. Such a culture-free detection method requires the capture and analysis of bacteria from a body fluid, which are usually of complicated composition. Here we show that coatingAg-nanoparticle arrays with vancomycin (Van) can provide label-free analysis of bacteria via surface-enhanced Raman spectroscopy (SERS), leading to a ~1,000-fold increase in bacteria capture, without introducing significant spectral interference. Bacteria from human blood can be concentrated onto a microscopic Van-coated area while blood cells are excluded. Furthermore, aVan-coated substrate provides distinctly different SERS spectra of Van-susceptible and Van-resistant Enterococcus, indicating its potential use for drug-resistance tests. Our results represent a critical step towards the creation of SERS-based multifunctional biochips for rapid culture- and label-free detection and drug-resistant testing of microorganisms in clinical samples.
Ref: Nature Communications 2, Article No. 538, Year 2011.

Transparent SERS Substrate:
Transparent Raman-enhancing substrates made of Ag nanoparticles on incompletely oxidized aluminum templates have been rendered transparent by an ion-drift process to complete the oxidation. The result shows that the transparent substrates exhibit high/uniform surface-enhanced Raman scattering (SERS) capability and good optical transmissivity, allowing for concurrent SERS characterization and high contrast transmission-mode optical imaging of S. aureus bacteria. We also demonstrate that the transparent substrates can used in conjunction with optical fibers as SERS sensors for in situ detection of malachite green down to 10 − 9 M.
Ref: Nanotechnology, vol. 22, page 385702, year 2011.
End
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