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Follow on Google News | Albumin depletion using Albusorb™ from serum samples to research glycoprotein Apolipoprotein C-IIIAuthors Holmberg et al published an article titled, “Lowering apolipoprotein CIII delays onset of type 1 diabetes” in the journal PNAS in which Albusorb™ is used for albumin depletion from rat serum samples.
By: Biotech Support Group Albusorb™ is an albumin depletion reagent supplied as a kit with necessary buffers. AlbuSorb™ comes from a silica-based, separation platform utilizing a new combination of surface microenvironments substituted with low molecular substrates that feature drug-binding motifs. Unlike immuno-affinity, the surfaces utilized are disposable eliminating cycle to cycle variance and cross-contamination. Characteristics of Albusorb™ Removes >90% albumin from 30 mg albumin/ml sample Affinity-type equivalence, virtually no cross-reactivity with other proteins Bind and elute procedure - simply weigh powder, condition the sample, centrifuge and/or filter, and recover the albumin depleted serum Economical new surface technology, not based on affinity chromatography Mild conditions maintain tertiary structure of proteins and simple transfer to secondary analysis The albumin depleted filtrate retains the enzymatic and biological activity Removes albumin from samples such as serum, plasma and from species including human, mouse, sheep, bovine, goat, rat, and calf The flow through fraction is compatible with LC-MS, activity based protein profiling and proteomic studies. For more information about AlbuSorb™, click: AlbuSorb™ Albumin Depletion Kit http://www.biotechsupportgroup.com/ About Biotech Support Group LLC Biotech Support Group LLC is a leading provider of genomics and proteomics sample preparation products and enrichment reagent kits as well as integrated biotechnology services for life sciences research, biomarker and drug discovery. Based in New Jersey, it’s principal products include: Albusorb™ CONTACT: Ravish Amin Biotech Support Group 1 Deer Park Drive, Suite M, Monmouth Junction, NJ 08852, USA 732-274-2866 sales@biotechsupportgroup.com AlbuSorb™ References Rat Serum Holmberg R, Refai E, Höög A.Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proceedings of the National Academy of Sciences.2011; http://www.pnas.org/ Cerebrospinal Fluid Gwenael Pottiez, Pawel Ciborowski. Proteomic Profiling of Cerebrospinal Fluid Expression Profiling In Neuroscience Neuromethods.2012; http://www.springerlink.com/ Serum Happonen KE, Fürst CM, Saxne T et al. PRELP protein inhibits the formation of the complement membrane attack complex.Journal of Biological Chemistry.2012; http://www.ncbi.nlm.nih.gov/ Holmberg R, Refai E, Höög A.Lowering apolipoprotein CIII delays onset of type 1 diabetes. Proceedings of the National Academy of Sciences.2011; http://www.pnas.org/ Tang MX, Ogawa K, Asamoto M. Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats Nutrition and Cancer.2011; http://www.researchgate.net/ Holmberg, Rebecka Apolipoprotein CIII and Ljungan virus in diabetes 2010. Doctoral Thesis http://publications.ki.se/ Lu Q, Zheng X, McIntosh T Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs. Analytical Chemistry.2009; http://www.ncbi.nlm.nih.gov/ End
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