In 1997, the first generation BNA (2’-O ,4’-C-methylene-
The third generation of 2’,4’-BNA-
Dr. Miguel Castro, CEO of Bio-Synthesis Inc. commented:
"In the past two decades we have seen the development of chemically modified oligonucleotides with enhanced binding properties to DNA and RNA. Most of these oligonucleotides also have increased affinity to complementary DNA. Some analogs such as Peptide Nucleic Acids (PNA) are fairly stable. However, they also have several disadvantages including a tendency to aggregate, limitation in size due to solubility issues and difficulty in integrating into chimeras of mixed oligos. The first generation BNA (2’,4’-BNA/
"We aim to expand our product offering with oligonucleotides which are sufficiently stable in physiological conditions and bind well to RNA complements. Variation of N-substitution at the 6-membered ring will result in additional advantages for biological applications. We are very excited to introduce BNA-NC oligonucleotides to the biomedical research community. These oligonucleotides will have a great impact in antisense, siRNA, SNP detection, FISH as well as a variety of diagnostic applications. BNA-NC can be used both as a primer and as a probe in a myriad of PCR and RT-PCR applications as well as applications in Molecular Biology research and commercial areas."
For more information please contact Bio-Synthesis, Inc. (http://www.biosyn.com/
Miguel Castro [migcas (at) biosyn (dot) com], President and CEO, Tel 972-420-8505 ext. 101
Heidi Fazeli [heidi (at) biosyn (dot) com], Sales & Marketing Director, Tel 972-420-8505 ext. 115
Bio-Synthesis is a manufacturer of custom peptide synthesis, antibodies, bioconjugation, DNA, RNA, BNA, organic synthesis, organic synthesis, gene synthesis, cloning, detection kits, cell line authentication, and a diverse number of bimolecular products for the biomedical/life science community worldwide.
With over 28 years of experience producing custom products for both research and pharmaceutical use, BSI has developed a reputation for both small and large scale synthesis using optimal processes that meet your specifications. BSI is a U.S. based company, therefore all products are exclusively manufactured at the state-of-the-