The authors evaluated the antibacterial and cytotoxic effects of L-Mesitran Soft and silver sulphadiazine (SSD) in a human burn wound model with Ps. aeruginosa. L-Mesitran Soft significantly reduced the bacterial load (5-log reduction) up to 24 h, SSD treatment left only a few bacteriae. In contrast, re-epithelialization (new tissue formation) was significantly reduced after application of SSD compared to L-Mesitran Soft or control.
SSD is still very much the 'golden standard' worldwide when treating burns. However, this publication cites that SSD is cytotoxic and delays wound healing.
The researchers show that L-Mesitran Soft is a good alternative and that it can speed up the healing of burn wounds. L-Mesitran can therefore be a contributing factor in healthcare cost reduction.
The Burns journal is a PubMed indexed journal. On the website of PubMed an abstract of the article can be found.