Posh go into the game on the back of a 1-1 draw at Birmingham City, while Middlesbrough were held to a draw at the Riverside Stadium.
Posh are set to be without full-back Mark Little for this weekend's clash, so Craig Alcock will move across to right-back and Tom Kennedy will slot in at left-back. David Hibbert and Scott Wootton are still sidelined by injury. Middlesbrough boss Tony Mowbray has no fresh injury problems ahead of the game. Mowbray has only two doubts with full-back Justin Hoyte and midfielder Kevin Thomson being assessed. Hoyte has missed the last two games with a hamstring problem, while a similar injury has sidelined the Scotland international for the last five.
However, the manager will definitely be without Scot Andy Halliday, who has joined League One Walsall on loan until January.
Boro head into the game on the back of a three-match unbeaten run, although last Saturday's 2-2 home draw with Blackpool, in which they led twice, enabled Cardiff to leapfrog them into third place in the table behind West Ham and leaders Southampton.
Posh defeated Derby County 3-2 in their last fixture at London Road with Grant McCann firing the winner in stoppage time.
'We obviously know a bit about Middlesbrough because we played them earlier in the campaign and they are an excellent side who have been in good form this season. Tony Mowbray and his assistant Mark Venus are a good management team and they play football the right way,' Ferguson said.
MATCH DAY MAGAZINE
Saturday's match day magazine includes exclusive interviews with Craig Alcock, Ian Bennett and Sky Sports News presenter Hayley McQueen, while Talksport's Adrian Durham looks at whether Huddersfield Town's unbeaten run deserves the coverage it has received. The magazine costs £3.