This new capability means Metrics now offers clients with potent and cytotoxic drugs another avenue toward Phase I first-time-in-
“Clearly there’s still a great deal of debate within the pharmaceutical industry about the value of neat API dosing and what role formulation can or should play when bringing new medicines to trial or market,” Cascone said. “At Metrics, we want to offer each client an individualized solution that works best for their specific product. Making neat API dosing available to clients with potent and cytotoxic products is one more way we can do that.”
The active-only, powder-in-capsule approach has become increasingly popular for the pharmaceutical industry mainly because it’s faster – allowing companies to get prospective new drugs into clinical trials more quickly.
Metrics’ potent facility is unique within the contract pharmaceutical development and manufacturing industry for how it provides total engineered containment of all processes through customized hard-wall isolation technologies. Its two processing rooms come complete with independent entry double airlocks, independent decontamination showers and exit airlocks, independent equipment airlocks, and access to a dedicated washroom. It is designed for one-way flow of material, personnel and equipment.
The facility’s dedicated air handler brings in 100-percent outside air with HEPA-in and HEPA-out filtering at the rate of 11,000-cubic-
Thanks to these measures, Metrics eliminated the need for powered air purifying respirators (PAPRs). And after every campaign, Metrics employees conduct comprehensive health-based cleaning verification of shared surface areas.
Metrics Inc. is one of the most respected contract pharmaceutical development and manufacturing companies in the United States today.
Started as an analytical laboratory in 1994, Metrics has evolved into a full-service provider of quality pharmaceutical formulation development;
Headquartered in Greenville, N.C., Metrics has particular expertise in FTIM and Phase I, II, and III CTM manufacturing. The company has conducted more than 120 FTIM projects for different chemical entities in the last five years alone – while developing more than 700 batches of CTM in the same period. To learn more, visit http://www.metricsinc.com