Changes in Brain Function in Early HIV Infection: A Reliable Indicator of Disease Prognosis?
New Rochelle, NY—Measurable changes in brain function and communication between brain regions may be a consequence of virus-induced injury during the early stages of human immunodeficiency virus (HIV) infection. These abnormalities and their implications in disease prognosis are detailed in an article in the groundbreaking new neuroscience journal Brain Connectivity (http://www.liebertpub.com/
Diminished cognitive function will develop in about half of individuals infected with HIV, which may include deficits in memory, attention, psychomotor capabilities, or verbal fluency. Evidence of cognitive decline in HIV infection has implications for prognosis, reduced survival time, and increased risk of death.
Xue Wang and colleagues from Northwestern University (Chicago and Evanston, IL) and North Shore University Health System (Evanston), used functional magnetic resonance imaging (fMRI) to obtain blood-oxygen-
“These findings indicate that changes in brain function are occurring very early in HIV infection, and subclinical alterations in functional connectivity may reflect vulnerability to cognitive decline,” says Ann Ragin, PhD, Principal Investigator and Research Professor, Northwestern University Medical School, Chicago, IL.
“Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection” is available free online for the next week at http://www.liebertpub.com/
Brain Connectivity is the journal of record for researchers and clinicians interested in all aspects of brain connectivity. The Journal is under the leadership of founding and Co-Editors-in-
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Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Journal of Neurotrauma and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 70 journals, newsmagazines, and books is available at www.liebertpub.com