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Follow on Google News | TSRHC Researchers Discover Genes Associated with Idiopathic ScoliosisNew Discovery at TSRHC Yields Additional Clues to Understanding Most Common Spinal Deformity in Children
By: Texas Scottish Rite Hospital for Children The new discovery follows the research team’s identification, in 2007, of the first gene associated with idiopathic scoliosis http://www.tsrhc.org/ Following earlier family-based studies with the common goal of identifying genes that contribute to idiopathic scoliosis, the research team conducted genome-wide association studies that discovered new potential disease-influencing genes in 419 Texas families with a confirmed idiopathic scoliosis diagnosis. Further analyses of these findings were conducted in more than 1,000 additional idiopathic scoliosis cases and controls from Texas and other parts of the United States. Most significant findings centered on two additional genes, CHL1 and DSCAM,which play a role in the neurologic and spinal systems. These findings will allow the medical community to form new hypotheses to explain what causes the condition and provide tools for future research. Dr. Swarkar Sharma is the lead author of the study that appeared in the April 2011 issue of the Human Molecular Genetics journal. “This study provides the most definitive link yet between the neurological and spinal system and scoliosis,” said Dr. Wise. “For many decades scoliosis has been addressed as a disease of the bones and muscles. This research suggests that the nervous system may be important in the disease and is pointing us toward genes that tell the patient’s nerves how to grow. We believe the study will allow us to narrow our research focus on the path toward a brighter future for our young patients.” Most often seen in otherwise healthy children, idiopathic scoliosis is an S- or C-shaped curvature of the spine, as viewed from the front, which develops as the child grows. Onset typically occurs during the rapid adolescent growth period, and children who are still growing, particularly girls, are at the greatest risk for developing severe idiopathic scoliosis. A condition first documented by ancient Greeks, idiopathic scoliosis affects populations worldwide. “This discovery lays additional groundwork for future research that will hopefully identify the specific abnormalities which cause the spine curvature,” said Dr. Tony Herring, chief of staff at TSRHC. “When we understand these mechanisms, we may be able to develop improved prevention and treatment methods.” With expert researchers, biomedical engineers, physicians, staff and patients all under the same roof, TSRHC has a record of multidisciplinary collaboration that generates an exceptional number of patents, discoveries and improved treatments for patients. The hospital’s prestigious research efforts and innovative scoliosis treatment methods http://www.tsrhc.org/ More help is needed in the groundbreaking research to find and fight the causes of scoliosis http://www.tsrhc.org/ Funding for the Research This research was funded through a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Grant R01 HD052973). The hospital’s work also is made possible through the establishment of the Pediatric Molecular Genetics Research Laboratory at Texas Scottish Rite Hospital for Children, which was funded by: The Crystal Charity Ball 1997; Beneke Companies; Horace C. Cabe Foundation; The Cain Foundation, in honor of Effie Marie Cain; The Florence Foundation; The Hillcrest Foundation, founded by Mrs. W. W. Caruth, Sr.; Hoblitzelle Foundation; The Hoglund Foundation; Kimberly Clark Corporation; About TSRHC: Texas Scottish Rite Hospital for Children is one of the nation's leading pediatric centers for the treatment of orthopaedic conditions, such as scoliosis http://www.tsrhc.org/ End
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