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Follow on Google News | The “Berlin Patient” as a Proof of Concept for an HIV CureLast December, Doctors from Germany published the first documented case of a HIV infection cure.
By: Alain Lafeuillade HIV always persists in treated patients due to the existence of life-long viral reservoirs which are not influenced by current antiretrovirals. Previous attempts to get rid of these reservoirs were all failures. In December 2010, a German team published the cure of an HIV-infected patient who received 2 bone marrow transplants for a relapsing leukemia. The bone marrow donor was chosen having a rare condition which is a genetic deletion on the CCR5 coding gene. The CCR5 is one of the co-receptors used by HIV to enter cells. Persons bearing this genetic defect are particularly resistant to HIV infection. Timothy Ray Brown, the “Berlin patient” stopped his antiretroviral medications at the time of the first transplant….and HIV never came back. With 4 years of follow up now, not any trace of HIV can be found in his body. Allogenic bone marrow transplants are difficult procedures and the CCR5 deletion is a rare defect, making this case not “the” solution for HIV cure. However it renewed enthusiasm in the scientific field and allowed to get stronger financial support from governmental agencies, like the NIH (National Institutes of Health). Several research groups are working on new strategies to “purge” or “control” the HIV reservoir, either with new drug compounds or gene therapy. A “Global Scientific Strategy Towards an HIV Cure” has been set up under the initiative of the IAS (International AIDS Society). “I am very pleased that my cure can be used as a catalyst to work for a universal cure of HIV as well as other diseases not necessarily related to HIV” modestly told us Timothy Ray Brown in a recent interview. Actually, he is the cornerstone of a new revolution happening in the HIV field. The interview is available at: http://www.hiv- Contact: Alain Lafeuillade CHITS 83000 Toulon France 33-4-94616340 lafeuillade@ http://www.hiv- End
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