PRLog - Jul. 12, 2011 - NEW YORK -- July 12, 2011 (New York, NY) – A leading IVF center in NY has announced research suggesting that genetic control over the mother’s immunologic tolerance of embryos is behind some IVF failures. According to the Center for Human Reproduction, genetics can have an effect on the implantation of embryos. After over four million IVF babies worldwide and a Nobel Prize in Medicine and Physiology to recognize the accomplishment, the reality of IVF is that more IVF cycles still fail than succeed.
A majority of failed IVF cases (and miscarriages)
Why the maternal immune system tolerates this “transplant”
A follow-up study, also in the medical journal PLoS ONE, suggested that FMR1 differences are also likely responsible for variations in IVF pregnancy rates in different races/ethnicities.2
David H. Barad, MD, the Center’s Clinical Director of IVF explains: “We now have evidence that IVF outcome differences associated with FMR1 affect implantation. They are likely immunologic in nature.” These are the first reported genetic controls for IVF outcomes. “This genetic component to embryo implantation may lead to prognostications, based on IVF patients’ genetic profiles,” adds Dr. Gleicher. “Potentially, then, these prognostications may open up revolutionary new avenues to therapies to improve implantation and IVF pregnancy chances through immunologic treatments.”
1Gleicher et al., PLoS ONE 2010; 5(12): e15303; 2Gleicher et al., PLoS ONE 2011; 6(4): e18781
Center for Human Reproduction (http://www.centerforhumanreprod.com/