You can see how to fix Duke Nukem Forever load times here:
The bottom line with this game is that it's got a LOT of advanced graphics options, which are going to continually lead it to run slower and with problems. We've found that in order to fix this, you have to be able to fix the various issues that will be preventing the game from being able to operate, allowing your system to operate in a much smoother and more effective way. To do this, we highly recommend you first ensure that you're able to repair any of the problems that the game has (by re-installing it), as well as then cleaning up the files and settings which will be causing it to run slower.
We've found the best way to make Duke Nukem Forever run faster is to first ensure that you can fix the various problems that will be preventing the game from being able to operate, and then make sure that Windows can run faster by using the likes of a Registry Cleaner. The good news is that in order to make this game run faster, you need to be able to repair any of the potential issues that Duke Nukem Forever could have with its settings, through using a piece of software called a "Registry Cleaner" tool.
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PersonalComputerFixes.com is a leading website which has been created to help you fix any of the problems and errors which could be causing your system to run slower. You can use the steps outlined on this website to fix the problems you may be facing on your system.