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Jan. 31, 2011 - PRLog -- African Mango research

There is indeed research on African Mango (Irvingia gabonensis). More precisely there is research on an extract from the seeds of the African mango tree. The extract is dubbed IGOB131. I am telling you this because if you try Irvingia gabonensis weight loss supplements, this is the ingredient that the research was conducted on. Other African mango extracts may not have the same effect.

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In one 4 long week study, published in 2005 in the Journal Lipids in Health and Disease, 40 overweight people were given either 3.15 grams of Irvingia gabonensis or a comparable amount of oat bran  30 minutes before meals, in conjunction with a low fat diet. People ate about 1800 calories a day.  At the end of this 4 week study, those receiving Irvingia gabonensis lost about 5.6% of body weight vs. those in the placebo group who  lost about 1% of body weight. Body fat did not change significantly in either group.

Body fat was measured using bioelectric impedance analysis, a method commonly used in health clubs. This method, while quick and easy to administer, is less accurate than other means like hydrostatic weighing,  Bod Pod etc.

Systolic blood pressure (the top blood pressure number) was reduced about 4 points after the 4 week  study. This drop in systolic blood pressure could be simply due to the weight loss experienced as opposed to a direct effect of Irvingia gabonensis itself.

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In a 10 week study, published in 2009 in the journal, Lipids in Health and Disease, 102 healthy overweight men and women were followed for 10 weeks. People were split into either a placebo group or a group that received 350 mg of Irvingia gabonensis. The Irvingia gabonensis was supplied by Gateway Health Alliances Inc (Fairfield CA).

In those receiving the Irvingia gabonensis extract, body weight, body fat and waist circumference had decreased more than in the placebo group. Those getting IGOB131 lost 28 pounds vs. about 1 pound for those getting the placebo. Body fat was determined using bioelectric impedance analysis.

LDL cholesterol (bad cholesterol), total cholesterol, blood glucose, and C reactive protein were also lower in those who received the Irvingia gabonensis extract.

The weight loss observed in the African Mango group could account for the the decreases in cholesterol, blood glucose and C reactive protein. These things do change when people lose weight. The soluble fiber in the extract may also had an effect on cholesterol levels.

Another study published in 2009 in Lipids in Health and Disease by the same researchers exposed mouse cells to IGOB131 and noted that the compound increased fat cell production of adiponectin. Research finds that adiponectin has anti inflammatory properties and that high levels of adiponectin appear to be correlated with a lower a lower risk of heart disease. This same study noted that IGOB131 inhibited fat cell development as well.

African mango and leptin

The 10 week long study published in 2009 also noted that the IGOB131 extract reduced levels of leptin. Leptin is a hormone made inside fat cells which plays a role in appetite. Basically this is what happens:

   * When leptin levels rise, we stop eating
   * When leptin levels fall, we get hungry

That’s the easy answer. The amount of leptin we have is dependent on how much body fat we have. So, the more body fat, the higher the leptin levels. One problem however is that many overweight people (who make a lot of leptin) are insensitive to the leptin and it doesn’t work to stop them from eating. In other words they are leptin resistant.

Because Irvingia gabonensis lowered leptin levels, some take this to mean that it helps weight loss. But, remember that as leptin levels decrease, we get hungry. I’m saying this because the decrease in leptin that was observed in the 10 week long 2009 study appear to be a result of IGOB131 reducing fat cell growth and differentiation. In other words, as fat cell growth slows, leptin levels might fall also.

If the African mango extract does reduce leptin levels, would a continued drop in leptin cause a rebound hunger in people, causing them to eat more? I don’t know? The longest study so far has only lasted 10 weeks. The bottom line to all this talk about leptin is that leptin is not the only player in the game when it comes to obesity. If Irvingia gabonensis has any real effect on combating weight loss, its effects on leptin are probably not the answer.

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