Otava Building Blocks in Combinatorial Chemistry

Aug. 18, 2010 - PRLog -- Building blocks are privileged structural motifs with various reactive functional groups including aldehydes, carboxylic acids, amines, and sulfonyl chlorides which are useful for incorporation into various scaffolds.
Rapid development of combinatorial chemistry and high throughput screening techniques in recent years has provided a powerful alternative to traditional approaches for lead generation and optimization.  The goal of combinatorial chemistry is to generate libraries with maximum chemical diversity of the composing compounds.  Combinatorial chemistry involves systematic assembly of a set of “building blocks” to generate larger libraries of chemically different molecules.
Pharmacophoric building blocks can be used in lead discovery and optimization.  Medicinal chemists utilize them to increase scaffold diversity and differentiation.
OTAVA specializes in synthesis and distribution of building blocks for high-throughput and combinatorial synthesis of pharmaceutical libraries or scale-up of lead compounds for further development.
Our company offers over 400,000 building-block compounds with many unique structures in multi-gram quantities.  OTAVA provides new building blocks that can help solve some of the problems incurred in drug discovery.

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OTAVA Ltd. is an international science-based chemical company founded in 1997. It has production laboratories and offices in Europe (Kiev, Ukraine) and North America (Toronto, Canada).