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Follow on Google News | Datamonitor: World Congress on Osteoporosis highlights changing face of bone healthDatamonitor attended this year's International Osteoporosis Foundation World Congress on Osteoporosis and 10th European Congress on Clinical and Economical Aspects of Osteoporosis and Osteoarthritis, ...
By: reports-research.com Pfizer: remains a small presence in the osteoporosis market The presence of Pfizer at the congress suggests that the company intends to launch Conbriza (bazedoxifene) Conbriza - also known as Viviant in the US - is a novel once-daily oral selective estrogen receptor modulator (SERM) developed by Pfizer for the treatment of postmenopausal osteoporosis. Conbriza was approved by the European Medicines Agency (EMA) in April 2009, but has not yet launched and is currently being reviewed by the FDA for the same indication. Conbriza was also filed in Japan in 2007. There have been several safety and efficacy issued with the use of SERMs for osteoporosis which have resulted in the recent decrease in sales of the only drug in this class on the market, Eli Lilly's Evista (raloxifene) Sanofi-Aventis/ Sanofi-Aventis has been marketing the leading brand Actonel (risedronate) Out of the 5,321 women in GLOW who were taking osteoporosis drugs at baseline, 19% had stopped after the first year. The most common reason was due to doctor's advice (37%) or side effects or long-term risk concerns (37%). No particular differences were seen in the discontinuation patterns and reasons among women who were taking bisphosphonates or non-bisphosphonate drugs. Datamonitor believes that this is a very interesting study which will allow researchers to better understand the behavior of women in taking the osteoporosis medications. GlaxoSmithKline: GlaxoSmithKline's presence at the conference demonstrated its continued commitment to osteoporosis. Together with its partners Amgen and Roche, it hosted key lunch symposia on denosumab and Bonviva. The company also presented data regarding its calcilytic compound ronacaleret, which recently failed Phase II trails. Investigation of ronacaleret was terminated after Phase II trials failed to show efficacy of the compound in increasing bone mineral density (BMD). The calcium-sensing receptor in parathyroid cells regulates the secretion of parathyroid hormone (PTH). By antagonizing the receptor it was thought that there would be an increase in PTH secretion and therefore an increase in BMD. The Phase II data presented were from a dose finding study (100mg, 200mg, 300mg or 400mg) and included an active comparator (alendronate 70mg) and an open label teriparatide arm. It was seen that patients taking ronacaleret had experienced an increase in lumbar spine BMD but this was lower than what was seen in patients taking alendronate and teriparatide. The authors suggest that ronacaleret caused a mild sustained primary hyperparathyroidism and did not produce the anabolic effect that had been anticipated from preclinical trials. Datamonitor notes that there are several other similar compounds in development for the treatment of osteoporosis. The negative data presented at the conference could suggest that there is a class issue with these novel compounds and therefore they may never reach the market. Nevertheless, experts at the congress are still very intrigued by the compounds and believe that others may be more efficacious in increasing BMD. As such, Datamonitor believes that calcilytic compounds remain attractive therapeutic targets for the time being. Datamonitor: http://www.reports- Datamonitor: http://www.reports- # # # markt-studie.de, founded in 2002 has emerged as a leading online portal for market surveys and market research in German speaking areas. Four years later the English language portal reports-research.com was introduced due to the extraordinary success of the portal. Again one year later estudio-mercado.es - the Spanish spoken portal - was founded. The objective of the three portals is to competently and efficiently support consultants and decision makers in management, sales and marketing in the search for worldwide market research. Prospective buyers can look into more than 60,000 market surveys from more than 200 international publishers, current market data for more than 6,000 branches worldwide, 10,000 company profiles as well as a free-of-charge research and recommendation service for individual market research. End
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