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Alto Marketing Limited Logo

Q Chip To Develop Biopharmaceutical Portfolio Based On Its Established Bioencapsulation Technology

A SEM of a Q Chip’s Q-Sphera™ PLGA microsphere
 

FOR IMMEDIATE RELEASE

PR Log (Press Release)Sep 25, 2009 – Cardiff, UK: – Q Chip, a biopharmaceutical drug delivery company, is developing a range of sustained-release biosimilars using its patented Q-Sphera™ bioencapsulation platform.  Q-Sphera is an enabling technology for peptide and protein delivery and a lower cost formulation and production platform for biosimilars.

The first two drugs under development using the Q-Sphera delivery system are the biosimilars, Q-Leuprolide (primary indications in prostate cancer and endometriosis) and Q-Octreotide (primary indications in acromegaly, and palliative care).  Q-Leuprolide and Q-Octreotide are three- and one-month sustained release microsphere formulations respectively.  Q Chip’s Q-Sphera technology offers several potential solutions to overcome the issues with biotherapy delivery, most notably via minimisation of protein and peptidal degradation and lower cost of production. The Q-Sphera drug-loaded microspheres are produced using bioresorbable polymers, and at 80 microns in diameter are injectable using 27-29 needle gauge devices.

Encapsulation of biotherapies into bioresorbable microspheres enables sustained and improved drug delivery. Q-Sphera is manufactured using Q Chip’s established bio-encapsulation platform which eliminates many of the limitations of conventional pharmaceutical microencapsulation methods. In particular, Q-Sphera microparticles are monodisperse with a CV (coefficient of variance) of less than 2%. Particle size significantly influences drug release characteristics and there is a direct correlation between consistent particle size and consistent drug release and therapeutic performance.  Q-Sphera microspheres also typically have a high drug load with a correspondingly high activity.

Q-Leuprolide and Q-Octreotide are in pre-clinical phase with bioequivalence studies planned for completion in 2011.

“Our Q-Sphera technology has been perfected over the last 2 years to effectively protect and deliver biological molecules in a very controlled way”, said Ken Powell, Q Chip’s Executive Chairman. “Although realistic about the challenges, we are highly optimistic that these trials will be a success because of the significant advantages compared to conventional methods of encapsulation. As well as our advantageous technology, Q Chip is backed up by a management team that is experienced in the development of biopharmaceuticals augmented by a team of industry experts so we are well-placed to successfully deliver on this programme.”

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Email Contact:Click to email (Partial email =  @alto-marketing.com) Email Verified
Issued By:David Robinson
Phone:+44 1489 557672
Fax:+44 1489 559246
Address:Office 3 Universal Marina. Crableck Lane
:Sarisbury Green. Southampton
Zip:SO31 7AL
State/Province:Hampshire
Country:United Kingdom
Categories:Biotech, Research, Science
Last Updated:Sep 25, 2009
Shortcut:http://prlog.org/10354333

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